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Editorial Board
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| Guest Editors' Introduction |
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Local signalling in myocytes
31 October 2011
The complex functions of cells are controlled by a surprisingly small number of second messengers. Therefore, in order to allow diverse stimuli to produce stimuli-specific cellular outcomes, it is ess...
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Sarah Calaghan,
Derek Steele,
James N. Weiss
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295-297
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| Local Ca2+ Signaling |
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Local control in cardiac E–C coupling
10 May 2011
Abstract: The development of local control theories in cardiac excitation–contraction coupling solved a major problem in the calcium-induced calcium release (CICR) hypothesis. Local control explained ...
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M.B. Cannell,
Cherrie H.T. Kong
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298-303
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Dynamic local changes in sarcoplasmic reticulum calcium: Physiological and pathophysiological roles
11 July 2011
Abstract: Evidence obtained in recent years indicates that, in cardiac myocytes, release of Ca2+ from the sarcoplasmic reticulum (SR) is regulated by changes in the concentration of Ca2+ within the SR...
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Eric A. Sobie,
W.J. Lederer
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304-311
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Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes
13 June 2011
Abstract: Calmodulin (CaM) acts as a common Ca2+ sensor for many signaling pathways, transducing local Ca2+ signals into specific cellular outcomes. Many of CaM's signaling functions can be explained ...
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Jeffrey J. Saucerman,
Donald M. Bers
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312-316
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Unraveling the secrets of a double life: Contractile versus signaling Ca2+ in a cardiac myocyte
19 May 2011
Abstract: No other inorganic molecule known in biology is considered as versatile as Ca2+. In a vast majority of cell types, Ca2+ acts as a universal second messenger underlying critical cellular proc...
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Sanjeewa A. Goonasekera,
Jeffery D. Molkentin
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317-322
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| Cyclic Nucleotides and Gaseous Signaling Molecules |
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PDEs create local domains of cAMP signaling
25 August 2011
Abstract: In the light of the knowledge accumulated over the years, it becomes clear that intracellular cAMP is not uniformly distributed within cardiomyocytes and that cAMP compartmentation is requir...
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Delphine Mika,
Jérôme Leroy,
Grégoire Vandecasteele,
Rodolphe Fischmeister
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323-329
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Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: From contractility to remodeling
08 August 2011
Abstract: Cyclic guanosine 3′5′monophosphate (cGMP) is the common downstream second messenger of natriuretic peptides and nitric oxide. In cardiac myocytes, the physiological effects of cGMP are exert...
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Joanna Hammond,
Jean-Luc Balligand
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330-340
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Sub-cellular targeting of constitutive NOS in health and disease
19 September 2011
Abstract: Constitutive nitric oxide synthases (NOSs) are ubiquitous enzymes that play a pivotal role in the regulation of myocardial function in health and disease. The discovery of both a neuronal NO...
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Yin Hua Zhang,
Barbara Casadei
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341-350
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AKAPs: The architectural underpinnings of local cAMP signaling
19 May 2011
Abstract: The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have bee...
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Michael D. Kritzer,
Jinliang Li,
Kimberly Dodge-Kafka,
Michael S. Kapiloff
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351-358
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Carbon monoxide: A vital signalling molecule and potent toxin in the myocardium
27 May 2011
Abstract: Endogenous carbon monoxide (CO) is generated through the heme oxygenase-catalysed degradation of heme and is now established as an important, biologically active molecule capable of modulati...
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Chris Peers,
Derek S. Steele
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359-365
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| Membrane Microdomains |
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Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology
18 July 2011
Abstract: Compartmentation of signalling allows multiple stimuli to achieve diverse cellular responses with only a limited pool of second messengers. This spatial control of signalling is achieved, in...
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Robert D. Harvey,
Sarah C. Calaghan
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366-375
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Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes
25 August 2011
Abstract: Influx of Ca2+ through L-type Ca2+ channels (LTCCs) contributes to numerous cellular processes in cardiomyocytes including excitation–contraction (EC) coupling, membrane excitability, and tr...
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Jabe M. Best,
Timothy J. Kamp
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376-387
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Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte
27 June 2011
Abstract: Inotropy and lusitropy in the ventricular myocyte can be efficiently induced by activation of β1-, but not β2-, adrenoceptors (ARs). Compartmentation of β2-AR-derived cAMP-dependent signalli...
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David A. MacDougall,
Shailesh R. Agarwal,
Elizabeth A. Stopford,
Hongjin Chu,
Jennifer A. Collins,
Anna L. Longster,
John Colyer,
Robert D. Harvey,
Sarah Calaghan
et al.
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388-400
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| Metabolic Compartmentation |
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Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment
20 June 2011
Abstract: Orchestrated excitation–contraction coupling in heart muscle requires adequate spatial arrangement of systems responsible for ion movement and metabolite turnover. Co-localization of regulat...
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Alexey E. Alekseev,
Santiago Reyes,
Vitaly A. Selivanov,
Petras P. Dzeja,
Andre Terzic
et al.
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401-409
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AMP-activated protein kinase connects cellular energy metabolism to KATP channel function
25 August 2011
Abstract: AMPK is an important sensor of cellular energy levels. The aim of these studies was to investigate whether cardiac KATP channels, which couple cellular energy metabolism to membrane excitabi...
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Hidetada Yoshida,
Li Bao,
Eirini Kefaloyianni,
Eylem Taskin,
Uzoma Okorie,
Miyoun Hong,
Piyali Dhar-Chowdhury,
Michiyo Kaneko,
William A. Coetzee
et al.
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410-418
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Intracellular Energetic Units regulate metabolism in cardiac cells
27 July 2011
Abstract: This review describes developments in historical perspective as well as recent results of investigations of cellular mechanisms of regulation of energy fluxes and mitochondrial respiration b...
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Valdur Saks,
Andrey V. Kuznetsov,
Marcela Gonzalez-Granillo,
Kersti Tepp,
Natalja Timohhina,
Minna Karu-Varikmaa,
Tuuli Kaambre,
Pierre Dos Santos,
François Boucher,
Rita Guzun
et al.
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419-436
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Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells
08 August 2011
Abstract: The aim of this study was to investigate the possible role of tubulin βII, a cytoskeletal protein, in regulation of mitochondrial oxidative phosphorylation and energy fluxes in heart cells. ...
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Marcela Gonzalez-Granillo,
Alexei Grichine,
Rita Guzun,
Yves Usson,
Kersti Tepp,
Vladimir Chekulayev,
Igor Shevchuk,
Minna Karu-Varikmaa,
Andrey V. Kuznetsov,
Michael Grimm,
Valdur Saks,
Tuuli Kaambre
et al.
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437-447
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Mitochondrial adenine nucleotide transport and cardioprotection
19 September 2011
Abstract: Mitochondria are highly metabolically active cell organelles that not only act as the powerhouse of the cell by supplying energy through ATP production, but also play a destructive role by i...
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Samarjit Das,
Charles Steenbergen
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448-453
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Metabolic stress, reactive oxygen species, and arrhythmia
26 September 2011
Abstract: Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias are unclear....
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Euy-Myoung Jeong,
Man Liu,
Megan Sturdy,
Ge Gao,
Susan T. Varghese,
Ali A. Sovari,
Samuel C. Dudley
et al.
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454-463
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| Autocrine and Paracrine Signaling in the Heart |
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S100B-RAGE dependent VEGF secretion by cardiac myocytes induces myofibroblast proliferation
25 August 2011
Abstract: Post-infarct remodeling is associated with the upregulation of the receptor for advanced glycation end products (RAGE), the induction of its ligand the calcium binding protein S100B and the ...
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James N. Tsoporis,
Shehla Izhar,
Gerald Proteau,
Graham Slaughter,
Thomas G. Parker
et al.
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464-473
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Vascular smooth muscle cell-derived adiponectin: A paracrine regulator of contractile phenotype
19 September 2011
Abstract: Adiponectin is a cardioprotective adipokine derived predominantly from visceral fat. We recently demonstrated that exogenous adiponectin induces vascular smooth muscle cell (VSMC) differenti...
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Min Ding,
Ana Catarina Carrão,
Robert J. Wagner,
Yi Xie,
Yu Jin,
Eva M. Rzucidlo,
Jun Yu,
Wei Li,
George Tellides,
John Hwa,
Tamar R. Aprahamian,
Kathleen A. Martin
et al.
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474-484
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| Local Signaling in Hypertrophy and Failure |
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Focal adhesion kinase — The basis of local hypertrophic signaling domains
04 July 2011
Abstract: Focal adhesion kinase (FAK), a broadly expressed non-receptor tyrosine kinase which transduces signals from integrins, growth and hormonal factors, is a key player in many fundamental biolog...
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K.G. Franchini
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485-492
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Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways
28 October 2011
Abstract: The heart responds to sustained overload by hypertrophic growth in which the myocytes distinctly thicken or elongate on increases in systolic or diastolic stress. Though potentially adaptive...
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C.F.M.Z. Clemente,
J. Xavier-Neto,
A.P. Dalla Costa,
S.R. Consonni,
J.E. Antunes,
S.A. Rocco,
M.B. Pereira,
C.C. Judice,
B. Strauss,
P.P. Joazeiro,
J.R. Matos-Souza,
K.G. Franchini
et al.
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493-501
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Serotonin 5-HT2A receptor-mediated hypertrophy is negatively regulated by caveolin-3 in cardiomyoblasts and neonatal cardiomyocytes
29 July 2011
Abstract: The serotonin 5-HT2A receptor belongs to the G-protein-coupled receptors (GPCRs) superfamily and mediates the hypertrophic response to serotonin (5-HT) in cardiac myocytes. At present the re...
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Jeanne Mialet-Perez,
Romina D'Angelo,
Christelle Villeneuve,
Catherine Ordener,
Anne Nègre-Salvayre,
Angelo Parini,
Cécile Vindis
et al.
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502-510
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Reorganized PKA-AKAP associations in the failing human heart
13 June 2011
Abstract: Here we reveal that the characterization of large-scale re-arrangements of signaling scaffolds induced by heart failure can serve as a novel concept to identify more specific therapeutic tar...
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Thin-Thin Aye,
Siddarth Soni,
Toon A.B. van Veen,
Marcel A.G. van der Heyden,
Salvatore Cappadona,
Andras Varro,
Roel A. de Weger,
Nicolaas de Jonge,
Marc A. Vos,
Albert J.R. Heck,
Arjen Scholten
et al.
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511-518
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