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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Une cellule type?
DOI: 10.1016/j.yjmcc.2012.01.014
The function is called the Gaussian distribution or normal distribution with about equal frequency. We have used the two names interchangeably. However, these names reflect the two fundamentally diffe...
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Leighton T. Izu,
Ye Chen-Izu
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Editorial
(In Press Accepted Manuscript)
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06 February 2012 |
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MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction
DOI: 10.1016/j.yjmcc.2012.01.021
Abstract: The toll-like receptors (TLR) and myocardial infarction (MI) promote NF-κB-dependent inflammatory transcription and oxidative injury in myocardium. The multifunctional Ca2+/calmodulin-depend...
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Madhu V. Singh,
Swaminathan,
E.D. Luczak,
W. Kutschke,
R.M. Weiss,
M.E. Anderson
et al.
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Full-length article
(In Press Accepted Manuscript)
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06 February 2012 |
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Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes
DOI: 10.1016/j.yjmcc.2012.01.022
Abstract: This work was motivated by the incomplete characterization of the role of vascular endothelial growth factor-A (VEGF-A) in the stressed heart in consideration of upcoming cancer treatment op...
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Manuel Chiusa,
Sara-Lynn Hool,
Petra Truetsch,
Siamak Djafarzadeh,
Stephan M. Jakob,
Franziska Seifriz,
Stefan J. Scherer,
Thomas M. Suter,
Christian Zuppinger,
Stephan Zbinden
et al.
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Full-length article
(In Press Accepted Manuscript)
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06 February 2012 |
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Shear stress-induced activation of Tie2-dependent signaling pathway enhances reendothelialization capacity of early endothelial progenitor cells
DOI: 10.1016/j.yjmcc.2012.01.019
Abstract: Although endothelial progenitor cells (EPCs) play a pivotal role in the endothelial repair following arterial injury and shear stress has a beneficial effect on EPCs, however, the molecular ...
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Zhen Yang,
Wen-Hao Xia,
Yuan-Yuan Zhang,
Shi-Yue Xu,
Xing Liu,
Xiao-Yu Zhang,
Bing-Bo Yu,
Yan-Xia Qiu,
Jun Tao
et al.
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Full-length article
(In Press Accepted Manuscript)
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03 February 2012 |
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Regulation of microRNA Expression in the Heart by the ATF6 Branch of the ER Stress Response
DOI: 10.1016/j.yjmcc.2012.01.017
Abstract: A nodal regulator of endoplasmic reticulum stress is the transcription factor, ATF6, which is activated by ischemia and protects the heart from ischemic damage, in vivo. To explore mechanism...
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Peter J. Belmont,
Wenqiong J. Chen,
Donna J. Thuerauf,
Christopher C. Glembotski
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Full-length article
(In Press Accepted Manuscript)
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03 February 2012 |
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The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors
DOI: 10.1016/j.yjmcc.2012.01.018
Abstract: Natriuretic peptides (NPs) are best known for their ability to regulate blood vessel tone and kidney function whereas their electrophysiological effects on the heart are less clear. Here, we...
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Jeremy Springer,
John Azer,
Rui Hua,
Courtney Robbins,
Andrew Adamczyk,
Sarah McBoyle,
Mary Beth Bissell,
Robert A. Rose
et al.
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Full-length article
(In Press Accepted Manuscript)
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03 February 2012 |
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AMPK isoform expression in the normal and failing hearts
DOI: 10.1016/j.yjmcc.2012.01.016
Abstract: AMP-activated protein kinase (AMPK) is a master metabolic switch that plays an important role in energy homeostasis at the cellular and whole body level, hence a promising drug target. AMPK ...
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Maengjo Kim,
Mei Shen,
Soeun Ngoy,
Georgios Karamanlidis,
Ronglih Liao,
Rong Tian
et al.
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Full-length article
(In Press Accepted Manuscript)
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02 February 2012 |
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Alternatively Spliced Tissue Factor and Full-length Tissue Factor Protect Cardiomyocytes against TNF-α-induced Apoptosis
DOI: 10.1016/j.yjmcc.2012.01.015
Abstract: Tissue Factor (TF) is expressed in various cell types of the heart, such as cardiomyocytes. In addition to its role in the initiation of blood coagulation, the TF:FVIIa complex protects cell...
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U. Boltzen,
A. Eisenreich,
S. Antoniak,
A. Weithaeuser,
H. Fechner,
W. Poller,
H.P. Schultheiss,
N. Mackman,
U. Rauch
et al.
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Full-length article
(In Press Accepted Manuscript)
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02 February 2012 |
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microRNAs in cardiovascular development
DOI: 10.1016/j.yjmcc.2012.01.012
Abstract: Heart development requires precise temporal-spatial regulation of gene expression, in which the highly conserved modulation networks of transcription factors accurately control the signaling...
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Jinghai Chen,
Da-Zhi Wang
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Review article
(In Press Uncorrected Proof)
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27 January 2012 |
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The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development
DOI: 10.1016/j.yjmcc.2012.01.013
Abstract: Semilunar valve malformations are common human congenital heart defects. Bicuspid aortic valves occur in 2–3% of the population, and pulmonic valve stenosis constitutes 10% of all congenital...
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Chieh-Yu Lin,
Chien-Jung Lin,
Chen-Hao Chen,
Richard M. Chen,
Bin Zhou,
Ching-Pin Chang
et al.
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Full-length article
(In Press Uncorrected Proof)
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27 January 2012 |
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New insights into microRNA-29 regulation: A new key player in cardiovascular disease
DOI: 10.1016/j.yjmcc.2012.01.009
MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs (22 nucleotides) that represent a new elegant layer of post-transcriptional control of gene expression . They are thought...
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Yajaira Suárez,
Carlos Fernández-Hernando
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Editorial
(In Press Corrected Proof)
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20 January 2012 |
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Arrhythmogenic coupling between the Na+–Ca2 + exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes
DOI: 10.1016/j.yjmcc.2012.01.007
Abstract: Atrial fibrillation, the most common sustained arrhythmia, is believed to be triggered by ectopic electrical activity originating in the myocardial sleeves surrounding the pulmonary veins (P...
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Yosuke Okamoto,
Makoto Takano,
Takayoshi Ohba,
Kyoichi Ono
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Full-length article
(In Press Corrected Proof)
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20 January 2012 |
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Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy
DOI: 10.1016/j.yjmcc.2011.12.015
Abstract: Sympathetic stimulation enhances cardiac contractility by stimulating β-adrenergic signaling and protein kinase A (PKA). Recently, phospholemman (PLM) has emerged as an important PKA substra...
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Jason H. Yang,
Jeffrey J. Saucerman
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Full-length article
(In Press Uncorrected Proof)
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20 January 2012 |
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Role of regulatory T cells in atheroprotective effects of granulocyte colony-stimulating factor
DOI: 10.1016/j.yjmcc.2011.12.016
Abstract: We and others have previously reported that granulocyte colony-stimulating factor (G-CSF) prevents left ventricular remodeling and dysfunction after myocardial infarction in animal models an...
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Raita Uchiyama,
Hiroshi Hasegawa,
Yoshihito Kameda,
Kazutaka Ueda,
Yoshio Kobayashi,
Issei Komuro,
Hiroyuki Takano
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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The dynamic role of cardiac myosin binding protein-C during ischemia
DOI: 10.1016/j.yjmcc.2012.01.006
Abstract: Cardiac myosin binding protein C (cMyBP-C) is a myofibrillar protein important for normal myocardial contractility and stability. In mutated form it can cause cardiomyopathy and heart failur...
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Robert S. Decker,
Sakie Nakamura,
Marlene L. Decker,
Mareike Sausamuta,
Sammy Sinno,
Kathleen Harris,
Francis J. Klocke,
Irina Kulikovskaya,
Saul Winegrad
et al.
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Full-length article
(In Press Uncorrected Proof)
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19 January 2012 |
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Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy
DOI: 10.1016/j.yjmcc.2012.01.008
Abstract: Taking advantage of the unique model of slowly developing dilated cardiomyopathy in mice with cardiomyocyte-specific transgenic overexpression of activated Gαq protein (Tgαq*44 mice) we anal...
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Urszula Mackiewicz,
Elżbieta Czarnowska,
Magdalena Brudek,
Beata Pająk,
Monika Duda,
Krzysztof Emanuel,
Gabor Csanyi,
Andrzej Fedorowicz,
Elżbieta Grochal,
Urszula Tyrankiewicz,
Tomasz Skórka,
Ulrike Mende,
Bohdan Lewartowski,
Stefan Chłopicki
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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Myocardial edema: A translational view
DOI: 10.1016/j.yjmcc.2012.01.010
Abstract: Myocardial edema occurs in a large number of myocardial pathologies particularly during ischemia–reperfusion, and may contribute to cell dysfunction and death occurring in these conditions. ...
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David Garcia-Dorado,
Mireia Andres-Villarreal,
Marisol Ruiz-Meana,
Javier Inserte,
Ignasi Barba
et al.
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Review article
(In Press Uncorrected Proof)
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19 January 2012 |
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Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy
DOI: 10.1016/j.yjmcc.2012.01.005
Abstract: Spinal muscular atrophy (SMA) is a leading genetic cause of infantile death. Loss of a gene called Survival Motor Neuron 1 (SMN1) and, as a result, reduced levels of the Survival Motor Neuro...
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Monir Shababi,
Javad Habibi,
Lixin Ma,
Jacqueline J. Glascock,
James R. Sowers,
Christian L. Lorson
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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Transgenic swine: Expression of human CD39 protects against myocardial injury: Wheeler, CD39 reduces myocardial injury in swine
DOI: 10.1016/j.yjmcc.2012.01.002
Abstract: CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD-1) rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5′-nucleotidase (CD73) to adenosine, an anti-thrombotic and ...
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Debra G. Wheeler,
Matthew E. Joseph,
Shouvik D. Mahamud,
William L. Aurand,
Peter J. Mohler,
Vincent J. Pompili,
Karen M. Dwyer,
Mark B. Nottle,
Sharon J. Harrison,
Anthony J.F. d'Apice,
Simon C. Robson,
Peter J. Cowan,
Richard J. Gumina
et al.
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Short communication
(In Press Uncorrected Proof)
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16 January 2012 |
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Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature
DOI: 10.1016/j.yjmcc.2012.01.003
Abstract: ATP can differentially affect the micro- and macrovascular endothelial barrier. It has been shown that it can both increase and/or decrease macromolecule permeability of microvascular endoth...
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Dursun Gündüz,
Muhammad Aslam,
Uwe Krieger,
Lutz Becker,
Mathias Grebe,
Muhammad Arshad,
Daniel G. Sedding,
Frauke V. Härtel,
Yaser Abdallah,
Hans Michael Piper,
Reinhard K. Voss,
Thomas Noll
et al.
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Full-length article
(In Press Uncorrected Proof)
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16 January 2012 |
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The expanding world of post-translational modifications
DOI: 10.1016/j.yjmcc.2012.01.004
Phosphorylation has long been known to regulate protein activity and has played a central role in most signal transduction pathways. Indeed 20years ago, in 1992 the Nobel Prize in Medicine was awarded...
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Elizabeth Murphy,
Cam Patterson
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Editorial
(In Press Corrected Proof)
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13 January 2012 |
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Delayed endosome-dependent CamKII and p38 kinase signaling in cardiomyocytes destabilizes Kv4.3 mRNA
DOI: 10.1016/j.yjmcc.2012.01.001
Abstract: The Kv4.3 transient outward current (Ito) channel, which produces early repolarization in human cardiomyocytes, is downregulated with cardiac pathology. This is evident in cultured neonatal ...
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Chaoming Zhou,
Samantha L. Cavolo,
Edwin S. Levitan
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease
DOI: 10.1016/j.yjmcc.2011.12.013
Abstract: Studies of human diseased aortic valves have demonstrated increased expression of genetic markers of valve progenitors and osteogenic differentiation associated with pathogenesis. Three pote...
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Jonathan D. Cheek,
Elaine E. Wirrig,
Christina M. Alfieri,
Jeanne F. James,
Katherine E. Yutzey
et al.
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Full-length article
(In Press Corrected Proof)
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11 January 2012 |
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Introduction to the Special Issue on Coronary Blood Flow
DOI: 10.1016/j.yjmcc.2011.11.017
Some 25years ago, the coronary circulation was at the center stage of the basic science program at the annual Scientific Sessions of the American Heart Association meetings, with 4–5 oral sessions plu...
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William M. Chilian,
Gerd Heusch
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Editorial
(In Press Corrected Proof)
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09 January 2012 |
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Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death
DOI: 10.1016/j.yjmcc.2011.12.014
Abstract: Sudden cardiac death (SCD) is a prevalent cause of death in Western societies. Genome-wide association studies (GWAS) conducted over the last few years have uncovered common genetic variants...
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Iris C.R.M. Kolder,
Michael W.T. Tanck,
Connie R. Bezzina
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Review article
(In Press Corrected Proof)
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09 January 2012 |
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Measuring and evaluating the role of ATP-Sensitive K+ channels in cardiac muscle
DOI: 10.1016/j.yjmcc.2011.12.012
Abstract: Since ion channels move electrical charge during their activity, they have traditionally been studied using electrophysiological approaches. This was sometimes combined with mathematical mod...
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Eirini Kefaloyianni,
Li Bao,
Michael J. Rindler,
Miyoun Hong,
Tejaskumar Patel,
Eylem Taskin,
William A. Coetzee
et al.
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Review article
(In Press Corrected Proof)
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06 January 2012 |
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The mitochondrial KATP channel—Fact or fiction?
DOI: 10.1016/j.yjmcc.2011.12.011
Abstract: The mitochondrial ATP-dependent K+ channel (mitoKATP) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic ...
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Keith D. Garlid,
Andrew P. Halestrap
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Discussion
(In Press Corrected Proof)
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04 January 2012 |
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Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress
DOI: 10.1016/j.yjmcc.2011.12.009
Abstract: Elevated plasma homocysteine (Hcy) is a risk factor for cardiovascular disease. While Hcy has been shown to promote endothelial dysfunction by decreasing the bioavailability of nitric oxide ...
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Xu Wang,
Lei Cui,
Jacob Joseph,
Bingbing Jiang,
David Pimental,
Diane E. Handy,
Ronglih Liao,
Joseph Loscalzo
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Stimulation of the AT2 receptor reduced atherogenesis in ApoE−/−/AT1A−/− double knock out mice
DOI: 10.1016/j.yjmcc.2011.12.007
Abstract: AT1 receptor blockers (ARB) and in part ACE inhibitors (ACI) potentially exert beneficial effects on atherogenesis independent of AT1 receptor inhibition. These pleiotropic effects might be ...
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Vedat Tiyerili,
Cornelius F.H. Mueller,
Ulrich M. Becher,
Thomas Czech,
Martin van Eickels,
Andreas Daiber,
Georg Nickenig,
Sven Wassmann
et al.
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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Carbonic anhydrase XIV in the normal and hypertrophic myocardium
DOI: 10.1016/j.yjmcc.2011.12.008
Abstract: Two AE3 transcripts, full-length (AE3fl) and cardiac (AE3c) are expressed in the heart. AE3 catalyzes electroneutral Cl−/HCO3− exchange across cardiomyocyte sarcolemma. AE proteins associate...
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Lorena A. Vargas,
Bernardo V. Alvarez
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: Novel mechanisms for cardiovascular diseases
DOI: 10.1016/j.yjmcc.2011.12.005
Abstract: MicroRNA-29b has been reported to epigenetically regulate proatherogenic genes in response to oxLDL. Since transcription factors and epigenetic regulations are important mechanisms to regula...
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Ku-Chung Chen,
Yi-Chu Liao,
I-Chung Hsieh,
Yung-Song Wang,
Ching-Yu Hu,
Suh-Hang Hank Juo
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Coronary collateral growth—Back to the future
DOI: 10.1016/j.yjmcc.2011.12.006
Abstract: The coronary collateral circulation is critically important as an adaptation of the heart to prevent the damage from ischemic insults. In their native state, collaterals in the heart would b...
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William M. Chilian,
Marc S. Penn,
Yuh Fen Pung,
Feng Dong,
Maritza Mayorga,
Vahagn Ohanyan,
Suzanna Logan,
Liya Yin
et al.
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Review article
(In Press Corrected Proof)
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21 December 2011 |
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Increased neointimal formation in cystathionine gamma-lyase deficient mice: Role of hydrogen sulfide in α5β1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells
DOI: 10.1016/j.yjmcc.2011.12.004
Abstract: The physiological and pathological roles of hydrogen sulfide (H2S) in the regulation of cardiovacular functions have been recognized. Vascular smooth muscle cells (SMCs) express cystathionin...
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Guangdong Yang,
Hongzhu Li,
Guanghua Tang,
Lingyun Wu,
Kexin Zhao,
Qiuhui Cao,
Changqing Xu,
Rui Wang
et al.
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Full-length article
(In Press Corrected Proof)
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21 December 2011 |
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Pathophysiology of the cardiac late Na current and its potential as a drug target
DOI: 10.1016/j.yjmcc.2011.12.003
Abstract: A pathological increase in the late component of the cardiac Na+ current, INaL, has been linked to disease manifestation in inherited and acquired cardiac diseases including the long QT vari...
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Jonathan D. Moreno,
Colleen E. Clancy
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Review article
(In Press Corrected Proof)
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19 December 2011 |
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Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy
DOI: 10.1016/j.yjmcc.2011.12.002
Abstract: Despite its significant clinical implications, physiological hypertrophy remains poorly understood. In this study, the transcription coactivator Eya2 was shown to be up-regulated during phys...
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Seung Hee Lee,
Jooyeon Kim,
Joo Young Ryu,
Suho Lee,
Dong Kwon Yang,
Dongtak Jeong,
Jaetaek Kim,
Sang-Hee Lee,
Jin Man Kim,
Roger J. Hajjar,
Woo Jin Park
et al.
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Full-length article
(In Press Corrected Proof)
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16 December 2011 |
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MicroRNA-20a inhibits stress-induced cardiomyocyte apoptosis involving its novel target Egln3/PHD3
DOI: 10.1016/j.yjmcc.2011.12.001
Abstract: Excessive stress, e.g. due to biomechanical overload or ischemia/reperfusion is a potent inductor of cardiomyocyte apoptosis, which contributes to maladaptive remodeling. Despite substantial...
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Derk Frank,
Johanne Gantenberg,
Inka Boomgaarden,
Christian Kuhn,
Rainer Will,
Kai-Uwe Jarr,
Matthias Eden,
Kristin Kramer,
Mark Luedde,
Heimo Mairbäurl,
Hugo A. Katus,
Norbert Frey
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability
DOI: 10.1016/j.yjmcc.2011.11.016
Abstract: The autonomic phenotype of congestive cardiac failure is characterised by high sympathetic drive and impaired vagal tone, which are independent predictors of mortality. We hypothesize that i...
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Neil Herring,
James Cranley,
Michael N. Lokale,
Dan Li,
Julia Shanks,
Eric N. Alston,
Beatrice M. Girard,
Emma Carter,
Rodney L. Parsons,
Beth A. Habecker,
David J. Paterson
et al.
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Full-length article
(In Press Corrected Proof)
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09 December 2011 |
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Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure
DOI: 10.1016/j.yjmcc.2011.11.015
Abstract: The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in a...
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Nassiba Merabet,
Jeremy Bellien,
Etienne Glevarec,
Lionel Nicol,
Daniele Lucas,
Isabelle Remy-Jouet,
Frederic Bounoure,
Yvonne Dreano,
Didier Wecker,
Christian Thuillez,
Paul Mulder
et al.
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Full-length article
(In Press Corrected Proof)
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07 December 2011 |
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Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction
DOI: 10.1016/j.yjmcc.2011.11.014
Abstract: Human studies indicate augmented myocardial lipid metabolism in females, and that sex and obesity interact to predict myocardial fatty acid oxidation and storage. Altered lipid dynamics prec...
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Natasha H. Banke,
Lin Yan,
Kayla M. Pound,
Sunil Dhar,
Heather Reinhardt,
Mariana S. De Lorenzo,
Stephen F. Vatner,
E. Douglas Lewandowski
et al.
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Full-length article
(In Press Corrected Proof)
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05 December 2011 |
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Reduced cardiac CapZ protein protects hearts against acute ischemia–reperfusion injury and enhances preconditioning
DOI: 10.1016/j.yjmcc.2011.11.013
Abstract: The Z-disc protein CapZ has historically been classified as a structural element, anchoring sarcomeric actin. Our previous work expanded its role to include signal transduction, as CapZ tran...
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Feng Hua Yang,
W. Glen Pyle
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Full-length article
(In Press Corrected Proof)
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05 December 2011 |
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The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase
DOI: 10.1016/j.yjmcc.2011.11.012
Abstract: Depressed Ca-handling in cardiomyocytes is frequently attributed to impaired sarcoplasmic reticulum (SR) function in human and experimental heart failure. Phospholamban (PLN) is a key regula...
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Kobra Haghighi,
Tracy Pritchard,
Julie Bossuyt,
Jason R. Waggoner,
Qunying Yuan,
Guo-Chang Fan,
Hanna Osinska,
Ahmad Anjak,
Jack Rubinstein,
Jeffrey Robbins,
Donald M. Bers,
Evangelia G. Kranias
et al.
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy
DOI: 10.1016/j.yjmcc.2011.11.009
Abstract: Cardiac hypertrophy is controlled by a complex signal transduction and gene regulatory network, containing multiple layers of crosstalk and feedback. While numerous individual components of ...
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Gregory T. Bass,
Karen A. Ryall,
Ashwin Katikapalli,
Brooks E. Taylor,
Stephen T. Dang,
Scott T. Acton,
Jeffrey J. Saucerman
et al.
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway
DOI: 10.1016/j.yjmcc.2011.11.010
Abstract: The efficient induction of cardiomyocyte differentiation from embryonic stem (ES) cells is crucial for cardiac regenerative medicine. Although Wnts play important roles in cardiac developmen...
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Takeshi Onizuka,
Shinsuke Yuasa,
Dai Kusumoto,
Kenichiro Shimoji,
Toru Egashira,
Yohei Ohno,
Toshimi Kageyama,
Tomofumi Tanaka,
Fumiyuki Hattori,
Jun Fujita,
Masaki Ieda,
Kensuke Kimura,
Shinji Makino,
Motoaki Sano,
Akira Kudo,
Keiichi Fukuda
et al.
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction
DOI: 10.1016/j.yjmcc.2011.11.011
Abstract: Sumoylation is a posttranslational modification implicated in a variety of cellular activities, and its role in a number of human pathogeneses such as cleft lip/palate has been well document...
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Eun Young Kim,
Li Chen,
Yanlin Ma,
Wei Yu,
Jiang Chang,
Ivan P. Moskowitz,
Jun Wang
et al.
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte
DOI: 10.1016/j.yjmcc.2011.11.007
Abstract: Cardiomyocytes release atrial natriuretic peptide (ANP) and B-type natriuretic peptide to stimulate processes that compensate for the failing heart by activating guanylyl cyclase (GC)-A. C-t...
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Deborah M. Dickey,
Daniel L. Dries,
Kenneth B. Margulies,
Lincoln R. Potter
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Full-length article
(In Press Corrected Proof)
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23 November 2011 |
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The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
DOI: 10.1016/j.yjmcc.2011.11.004
Abstract: Although acetyl-modification of protein lysine residues has been recognized for many decades, the appreciation that this post-translational modification is highly prevalent in mitochondria a...
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Michael N. Sack
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Review article
(In Press Corrected Proof)
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21 November 2011 |
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Back to your heart: Ubiquitin proteasome system-regulated signal transduction
DOI: 10.1016/j.yjmcc.2011.10.023
Abstract: Awareness of the regulation of cell signaling by post-translational ubiquitination has emerged over the past 2 decades. Like phosphorylation, post-translational modification of proteins with...
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Andrea L. Portbury,
Sarah M. Ronnebaum,
Makhosazane Zungu,
Cam Patterson,
Monte S. Willis
et al.
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Review article
(In Press Corrected Proof)
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07 November 2011 |
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The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance
DOI: 10.1016/j.yjmcc.2011.10.010
Abstract: We previously demonstrated a cardiac mitochondrial biogenic response in insulin resistant mice that requires the nuclear receptor transcription factor PPARα. We hypothesized that the PPARα c...
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Riddhi Mitra,
Daniel P. Nogee,
Juliet F. Zechner,
Kyungmoo Yea,
Carrie M. Gierasch,
Attila Kovacs,
Denis M. Medeiros,
Daniel P. Kelly,
Jennifer G. Duncan
et al.
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Full-length article
(In Press Corrected Proof)
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24 October 2011 |
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Regulation of coronary resistance vessel tone in response to exercise
DOI: 10.1016/j.yjmcc.2011.10.007
Abstract: Exercise is a primary stimulus for increased myocardial oxygen demand. The ~6-fold increase in oxygen demand of the left ventricle during heavy exercise is met principally by augmenting coro...
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Dirk J. Duncker,
Robert J. Bache,
Daphne Merkus
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Review article
(In Press Corrected Proof)
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17 October 2011 |
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Regulation of the human coronary microcirculation
DOI: 10.1016/j.yjmcc.2011.10.003
Abstract: Atherosclerosis of conduit epicardial arteries is the principal culprit behind the complications of coronary heart disease, but a growing body of literature indicates that the coronary micro...
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Andreas M. Beyer,
David D. Gutterman
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Review article
(In Press Corrected Proof)
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14 October 2011 |
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Mechanisms of metabolic coronary flow regulation
DOI: 10.1016/j.yjmcc.2011.10.001
Abstract: Coronary blood flow is tightly adjusted to the oxygen requirements of the myocardium. The underlying control mechanisms keep coronary venous pO2 at a rather constant level around 20mm Hg und...
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Andreas Deussen,
Vahagn Ohanyan,
Anett Jannasch,
Liya Yin,
William Chilian
et al.
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Review article
(In Press Corrected Proof)
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10 October 2011 |
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Peri-interventional coronary vasomotion
DOI: 10.1016/j.yjmcc.2011.09.017
Abstract: A percutaneous coronary intervention (PCI) is a unique condition to study the effects of ischemia and reperfusion in patients with severe coronary atherosclerosis when coronary vasomotor fun...
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Luisa Gregorini,
Jean Marco,
Gerd Heusch
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Review article
(In Press Corrected Proof)
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26 September 2011 |
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The coronary collateral circulation: Genetic and environmental determinants in experimental models and humans
DOI: 10.1016/j.yjmcc.2011.09.010
Abstract: Obstruction of coronary arteries leads to an arteriogenic response. Pre-existent collateral networks enlarge, forming large conductance arteries with the capability to compensate for the los...
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Paul F.A. Teunissen,
Anton J.G. Horrevoets,
Niels van Royen
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Review article
(In Press Corrected Proof)
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21 September 2011 |
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Redox modification of cell signaling in the cardiovascular system
DOI: 10.1016/j.yjmcc.2011.09.009
Abstract: Oxidative stress is presumed to be involved in the pathogenesis of many diseases, including cardiovascular disease. However, oxidants are also generated in healthy cells, and increasing evid...
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Dan Shao,
Shin-ichi Oka,
Christopher D. Brady,
Judith Haendeler,
Philip Eaton,
Junichi Sadoshima
et al.
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Review article
(In Press Corrected Proof)
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19 September 2011 |
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Role of inflammation in the regulation of coronary blood flow in ischemia and reperfusion: Mechanisms and therapeutic implications
DOI: 10.1016/j.yjmcc.2011.08.027
Abstract: A multitude of factors, including increased coronary vascular resistance and dysregulated coronary microcirculatory function, contribute to the impairment of coronary blood flow (CBF) regula...
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Jun Li,
Hanrui Zhang,
Cuihua Zhang
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Review article
(In Press Corrected Proof)
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07 September 2011 |
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The coronary circulation and blood flow in left ventricular hypertrophy
DOI: 10.1016/j.yjmcc.2011.08.028
Abstract: Two distinct types of left ventricular hypertrophy (LVH) have been described: the so called “physiologic” hypertrophy, which is normally found in professional athletes, and “pathologic” LVH ...
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Paolo G. Camici,
Iacopo Olivotto,
Ornella E. Rimoldi
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Review article
(In Press Corrected Proof)
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07 September 2011 |
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Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease
DOI: 10.1016/j.yjmcc.2011.08.019
Abstract: A large body of evidence has demonstrated that there is a close coupling between regional myocardial perfusion and contractile function. When ischemia is mild, this can result in the develop...
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John M. Canty,
Gen Suzuki
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Review article
(In Press Corrected Proof)
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29 August 2011 |
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S-nitrosylation: A radical way to protect the heart
DOI: 10.1016/j.yjmcc.2011.08.021
Abstract: In this review, the role of S-nitrosylation (SNO) in cardioprotection will be discussed. This review will cover the methodology used to measure SNO levels, and the mechanisms by which SNO se...
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Elizabeth Murphy,
Mark Kohr,
Junhui Sun,
Tiffany Nguyen,
Charles Steenbergen
et al.
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Review article
(In Press Corrected Proof)
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29 August 2011 |
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Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation
DOI: 10.1016/j.yjmcc.2011.08.018
Abstract: Diseases of the coronary circulation remain the leading cause of death in Western society despite impressive advances in diagnosis, pharmacotherapy and post-event management. Part of this st...
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Eric J. Belin de Chantemele,
David W. Stepp
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Review article
(In Press Corrected Proof)
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29 August 2011 |
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Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function
DOI: 10.1016/j.yjmcc.2011.08.009
Abstract: The post-translational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAc) is...
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Victor M. Darley-Usmar,
Lauren E. Ball,
John C. Chatham
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Review article
(In Press Corrected Proof)
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22 August 2011 |