Journal of Molecular and Cellular Cardiology
Volume 49, Issue 5 , Pages 836-840 , November 2010

Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: Genetic evidence of impaired tissue response to Fgf8

  • Francesca Vitelli

      Affiliations

    • Institute of Biosciences and Technologies, Texas A&M University, Houston, TX, USA
    • FV and GL have contributed equally to this work.
    • ,
  • Gabriella Lania

      Affiliations

    • Institute of Genetics and Biophysics of the National Research Council, Naples, Italy
    • FV and GL have contributed equally to this work.
    • ,
  • Tuong Huynh

      Affiliations

    • Institute of Biosciences and Technologies, Texas A&M University, Houston, TX, USA
    • ,
  • Antonio Baldini

      Affiliations

    • Institute of Biosciences and Technologies, Texas A&M University, Houston, TX, USA
    • Institute of Genetics and Biophysics of the National Research Council, Naples, Italy
    • Corresponding Author InformationCorresponding author. Institute of Genetics and Biophysics CNR, Via Pietro Castellino 111, 80131 Napoli, Italy.

Received 16 May 2010 ,Revised 11 August 2010 ,Accepted 24 August 2010.

References 

  1. Prall OW, Elliott DA, Harvey RP. Developmental paradigms in heart disease: insights from tinman. Ann. Med. 2002;34:148–156
  2. Chen L, Fulcoli FG, Tang S, Baldini A. Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ. Res. 2009;105:842–851
  3. Fulcoli FG, Huynh T, Scambler PJ, Baldini A. Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS ONE. 2009;4:e6049
  4. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007;128:947–959
  5. Vitelli F, Taddei I, Morishima M, Meyers EN, Lindsay EA, Baldini A. A genetic link between Tbx1 and fibroblast growth factor signaling. Development. 2002;129:4605–4611
  6. Vitelli F, Zhang Z, Huynh T, Sobotka A, Mupo A, Baldini A. Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev. Biol. 2006;295:559–570
  7. Lania G, Zhang Z, Huynh T, Caprio C, Moon AM, Vitelli F, et al. Early thyroid development requires a Tbx1–Fgf8 pathway. Dev. Biol. 2009;328:109–117
  8. Huynh T, Chen L, Terrell P, Baldini A. A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis. 2007;45:470–475
  9. Zhang Z, Huynh T, Baldini A. Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development. 2006;133:3587–3595
  10. Meyers EN, Lewandoski M, Martin GR. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet. 1998;18:136–141
  11. Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA. Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev. Biol. 2004;267:190–202
  12. Zhang Z, Baldini A. In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum. Mol. Genet. 2008;17:150–157
  13. Firnberg N, Neubuser A. FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region. Dev. Biol. 2002;247:237–250
  14. Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, et al. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 2008;135:3611–3622
  15. Guris DL, Duester G, Papaioannou VE, Imamoto A. Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev. Cell. 2006;10:81–92
  16. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006;133:2419–2433

PII: S0022-2828(10)00326-3

doi: 10.1016/j.yjmcc.2010.08.023

Journal of Molecular and Cellular Cardiology
Volume 49, Issue 5 , Pages 836-840 , November 2010

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