« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 50, Issue 2
, Pages 280-289
, February 2011
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
References
- Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. Feb 23; 121(7): e46-e215.
- . Regenerating the heart. Nat Biotechnol. Jul 2005;23(7):845–856
- Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism. Circulation. May 25 2004;109(20):2386–2393
- . Contribution of human hematopoietic stem cells to liver repair. Semin Immunopathol. Sep 2009;31(3):411–419
- . Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE. 2008;3(4):e1886
- . Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res. Nov 21 2008;103(11):1204–1219
- . Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair. 2008;1(1):4
- Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med. Apr 2005;11(4):367–368
- . Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions. Am J Physiol Heart Circ Physiol. Oct 2008;295(4):H1726–H1735
- LaFramboise WA, Petrosko P, Krill-Burger JM, Morris DR, McCoy AR, Scalise D, et al. Proteins secreted by embryonic stem cells activate cardiomyocytes through ligand binding pathways. J Proteomics. Mar 10; 73(5): 992-1003.
- Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation. Jan 28 2003;107(3):461–468
- Maxeiner H, Krehbiehl N, Muller A, Woitasky N, Akinturk H, Muller M, et al. New insights into paracrine mechanisms of human cardiac progenitor cells. Eur J Heart Fail. Jul; 12(7): 730-7.
- . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. Aug 25 2006;126(4):663–676
- . Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation. Aug 4 2009;120(5):408–416
- Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res. Feb 27 2009;104(4):e30–e41
- Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation. Apr 6 2004;109(13):1615–1622
- Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res. Oct 1 2004;95(7):742–748
- . Cellular transplantation: future therapeutic options. Curr Opin Cardiol. Mar 2007;22(2):104–110
- Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol. Aug 2006;291(2):H886–H893
- Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation. Aug 28 2001;104(9):1046–1052
- Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res. Jul 18 2008;103(2):203–211
- Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec. Sep 1 2001;264(1):51–62
- Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res. 2000;2(6):477–488
- Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. Apr 2001;7(2):211–228
- . Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Lab Invest. Aug 2005;85(8):962–971
- Chanda D, Kumar S, Ponnazhagan S. Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton. J Cell Biochem. May 19.
- Autologous transplantation of bone marrow cells improves damaged heart function. Circulation. Nov 9 1999;100(19 Suppl):II247–II256
- Bone marrow cells regenerate infarcted myocardium. Nature. Apr 5 2001;410(6829):701–705
- . Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res. Jul 9 2004;95(1):9–20
- Nguyen BK, Maltais S, Perrault LP, Tanguay JF, Tardif JC, Stevens LM, et al. Improved Function and Myocardial Repair of Infarcted Heart by Intracoronary Injection of Mesenchymal Stem Cell-Derived Growth Factors. J Cardiovasc Transl Res. Feb 26.
- Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. Apr 2006;20(6):661–669
- Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci USA. Jan 30 2007;104(5):1643–1648
- Novel Stem Cell Paracrine Factor Protects Cardiomyocytes Through Protein Kinase C Epsilon Selective Mechanism. Circulation. 2009;120:S846
- . Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. Jun 9 2006;98(11):1414–1421
- . Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells. PLoS ONE. 2010;5(4):e10237
- Kelly ML, Wang M, Crisostomo PR, Abarbanell AM, Herrmann JL, Weil BR, et al. TNF receptor 2, NOT tnf receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia. Shock. Jun; 33(6): 602-7.
- . Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension. Jul 2005;46(1):7–18
- Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. Mar 30 2004;109(12):1543–1549
- VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function. Am J Physiol Heart Circ Physiol. Dec 2008;295(6):H2308–H2314
- Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol. Dec 2004;287(6):H2670–H2676
- Direct injection of autologous mesenchymal stromal cells improves myocardial function. Biochem Biophys Res Commun. Dec 18 2009;390(3):902–907
- Abarbanell AM, Wang Y, Herrmann JL, Weil BR, Poynter JA, Manukyan MC, et al. Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. May; 298(5): H1529-36.
- TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease. J Pathol. Nov 2006;210(3):315–324
- . Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases. J Tissue Eng Regen Med. Mar 10 2010;
- . Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. Jul 2005;85(3):1093–1129
- Profound bioenergetic abnormalities in peri-infarct myocardial regions. Am J Physiol Heart Circ Physiol. Aug 2006;291(2):H648–H657
- Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells. Apr 2009;27(4):971–979
- The effects of mesenchymal stem cells transduced with Akt in a porcine myocardial infarction model. Cardiovasc Res. Jun 1 2006;70(3):530–542
- . Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation. Am J Physiol Heart Circ Physiol. Sep 2007;293(3):H1772–H1780
- Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure. J Cardiothorac Surg. 2006;1:17
- Bone marrow-derived stem cells attenuate impaired contractility and enhance capillary density in a rabbit model of Doxorubicin-induced failing hearts. J Card Surg. Sep-Oct 2009;24(5):591–599
- Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol. Aug 2005;33(2):145–152
- Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem. Aug 2007;40(12):893–899
- Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells. Dec 2009;27(12):3063–3073
- Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol. Jun 2006;290(6):H2196–H2203
- . Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction. Inflammation. Aug 2007;30(3–4):97–104
- . Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats. Coron Artery Dis. Jun 2005;16(4):245–255
- . Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells. Stem Cells. May 2007;25(5):1166–1177
- Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation. Aug 23 2005;112(8):1128–1135
- . Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett. Aug 21 2007;581(21):3961–3966
- Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis. J Mol Cell Cardiol. Jan 2007;42(1):88–97
- . A role for T lymphocytes in mediating cardiac diastolic function. Am J Physiol Heart Circ Physiol. Aug 2005;289(2):H643–H651
- Tang J, Wang J, Guo L, Kong X, Yang J, Zheng F, et al. Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction. Mol Cells. Jan; 29(1): 9-19.
- Psaltis PJ, Paton S, See F, Arthur A, Martin S, Itescu S, et al. Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations. J Cell Physiol. May; 223(2): 530-40.
- . Mesenchymal stem cells in arthritic diseases. Arthritis Res Ther. 2008;10(5):223
- . Wnt signaling controls the fate of mesenchymal stem cells. Gene. Mar 15 2009;433(1–2):1–7
- . Endothelial dysfunction. J Am Soc Nephrol. Aug 2004;15(8):1983–1992
- Paracrine factors secreted by endothelial progenitor cells prevent oxidative stress-induced apoptosis of mature endothelial cells. Atherosclerosis. Feb 24 2010;
- Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol. Nov 2005;39(5):733–742
- Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation. PLoS One. 2009;4(5):e5643
- Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1. Stem Cells Dev. Oct 2008;17(5):941–951
- Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am J Physiol Heart Circ Physiol. May 2009;296(5):H1675–H1682
- Human peripheral blood endothelial progenitor cells synthesize and express functionally active tissue factor. Thromb Res. Apr 2009;123(6):925–930
- . Cardiac stem/progenitor cells, secreted proteins, and proteomics. FEBS Lett. Jun 5 2009;583(11):1800–1807
- Stastna M, Chimenti I, Marban E, Van Eyk JE. Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics. Jan; 10(2): 245-53.
- Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, et al. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res. Mar 19; 106(5): 971-80.
- Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, et al. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. Jan 19; 121(2): 293-305.
- Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med. Feb 19 2007;204(2):405–420
- . Embryonic endothelial progenitor cell-mediated cardioprotection requires Thymosin beta4. Trends Cardiovasc Med. Aug 2008;18(6):205–210
- Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation. Apr 29 2008;117(17):2232–2240
- . Resident cardiac stem cells. Cell Mol Life Sci. Mar 2007;64(6):661–673
- VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature. Jun 27 2002;417(6892):954–958
- . Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther. 2007;9(1):204
- SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. Stem Cells. 2008 Jan;26(1):35–44
- The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci USA. Nov 25 2008;105(47):18366–18371
- . Autocrine and intracrine signaling for cardiogenesis in embryonic stem cells: a clue for the development of novel differentiating agents. Handb Exp Pharmacol. 2006;174:123–146
- . Secretome from mesenchymal stem cells induces angiogenesis via Cyr61. J Cell Physiol. Jun 2009;219(3):563–571
- Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res. Jan 2 2009;104(1):32–40
- . Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. Cardiovasc Res. May 1 2009;82(2):303–312
- High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol Syst Biol. 2009;5:258
- . Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res. Jan 2010;38(1):215–224
- . microRNAs in heart disease: putative novel therapeutic targets?. Eur Heart J. Mar 2010;31(6):649–658
- . Enhancing stem cell therapy through genetic modification. J Am Coll Cardiol. Oct 4 2005;46(7):1351–1353
- Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells. Aug 2007;25(8):2118–2127
- Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells. Dec 2009;27(12):3021–3031
- . Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol. Oct 4 2005;46(7):1339–1350
- Vascular endothelial growth factor-expressing mesenchymal stem cell transplantation for the treatment of acute myocardial infarction. Arterioscler Thromb Vasc Biol. Jun 2005;25(6):1168–1173
- Treatment of myocardial ischemia with bone marrow-derived mesenchymal stem cells overexpressing hepatocyte growth factor. Mol Ther. Sep 2003;8(3):467–474
- Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions. Mol Cells. Jun 30 2005;19(3):402–407
- Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran. Tissue Eng. Feb 2007;13(2):313–322
- SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J. Oct 2007;21(12):3197–3207
- Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. Sep 2003;9(9):1195–1201
- Huang J, Zhang Z, Guo J, Ni A, Deb A, Zhang L, et al. Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium. Circ Res. Apr 8.
- Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther. Mar 2008;16(3):571–579
- . Stable therapeutic effects of mesenchymal stem cell-based multiple gene delivery for cardiac repair. Cardiovasc Res. Feb 1 2008;77(3):525–533
- Cottage CT, Bailey B, Fischer KM, Avitable D, Collins B, Tuck S, et al. Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res. Mar 19; 106(5): 891-901.
- Embryonic stem cells overexpressing Pitx2c engraft in infarcted myocardium and improve cardiac function. Int Heart J. Nov 2009;50(6):783–799
- . Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem. Nov 27 2009;284(48):33161–33168
- . Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol. Oct 2008;45(4):554–566
- Hyaluronan mixed esters of butyric and retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts. J Biol Chem. May 11 2007;282(19):14243–14252
- . Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res. Jan 2008;77(1):134–142
- Herrmann JL, Wang Y, Abarbanell AM, Weil BR, Tan J, Meldrum DR. Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection. Shock. Jan; 33(1): 24-30.
- Regeneration of infarcted myocardium by intramyocardial implantation of ex vivo transforming growth factor-beta-preprogrammed bone marrow stem cells. Circulation. May 17 2005;111(19):2438–2445
- Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem Cell Res. Nov 2007;1(2):129–137
- . The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. May 1 2007;74(2):184–195
- . Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window. Cardiovasc Res. Feb 15 2006;69(3):604–613
- . Therapeutic angiogenesis in cardiology using protein formulations. Cardiovasc Res. Feb 16 2001;49(3):522–531
- . Recent advances in protein and peptide drug delivery systems. Curr Drug Deliv. Apr 2007;4(2):141–151
- Balasubramanian V, Onaca O, Enea R, Hughes DW, Palivan CG. Protein delivery: from conventional drug delivery carriers to polymeric nanoreactors. Expert Opin Drug Deliv Jan; 7(1): 63-78.
- Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci USA. May 23 2006;103(21):8155–8160
PII: S0022-2828(10)00292-0
doi: 10.1016/j.yjmcc.2010.08.005
© 2010 Elsevier Ltd. All rights reserved.
« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 50, Issue 2
, Pages 280-289
, February 2011
