Journal of Molecular and Cellular Cardiology
Volume 49, Issue 5 , Pages 801-811 , November 2010

An association between gene expression and better survival in female mice following myocardial infarction

  • Quanhai Chen

      Affiliations

    • Cardiovascular Health Research Center at Sanford Research/USD, Sioux Falls, SD, USA
  • ,
  • Roy Williams

      Affiliations

    • The Sanford/Burnham Medical Research Institute, San Diego, CA, USA
  • ,
  • Chastity L. Healy

      Affiliations

    • Cardiovascular Health Research Center at Sanford Research/USD, Sioux Falls, SD, USA
  • ,
  • Casey D. Wright

      Affiliations

    • Cardiovascular Health Research Center at Sanford Research/USD, Sioux Falls, SD, USA
  • ,
  • Steven C. Wu

      Affiliations

    • Cardiovascular Health Research Center at Sanford Research/USD, Sioux Falls, SD, USA
  • ,
  • Timothy D. O'Connell

      Affiliations

    • Cardiovascular Health Research Center at Sanford Research/USD, Sioux Falls, SD, USA
    • Corresponding Author InformationCorresponding author. Cardiovascular Health Research Center, Sanford Research/USD, 1100 E. 21st St. Suite 700, Sioux Falls, SD 57105, USA. Tel.: +1 605 328 1300; fax: +1 605 328 1301.

Received 14 January 2010 ,Revised 28 July 2010 ,Accepted 2 August 2010.

References 

  1. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, et al. Heart disease and stroke statistics—2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. Jan 29 2008;117(4):e25–e146
  2. Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA. Jul 3 2002;288(1):49–57
  3. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. Jul 17 2002;288(3):321–333
  4. Cavasin MA, Sankey SS, Yu AL, Menon S, Yang XP. Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction. Am J Physiol Heart Circ Physiol. May 2003;284(5):H1560–H1569
  5. Cavasin MA, Tao Z, Menon S, Yang XP. Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice. Life Sci. Sep 17 2004;75(18):2181–2192
  6. Cavasin MA, Tao ZY, Yu AL, Yang XP. Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function. Am J Physiol Heart Circ Physiol. May 2006;290(5):H2043–H2050
  7. Fang L, Gao XM, Moore XL, Kiriazis H, Su Y, Ming Z, et al. Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J Mol Cell Cardiol. Nov 2007;43(5):535–544
  8. Pelzer T, Loza PA, Hu K, Bayer B, Dienesch C, Calvillo L, et al. Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction. Circulation. Mar 29 2005;111(12):1492–1498
  9. Pedram A, Razandi M, Lubahn D, Liu J, Vannan M, Levin ER. Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin. Endocrinology. Jul 2008;149(7):3361–3369
  10. Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, et al. 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circ Res. Oct 1 2004;95(7):692–699
  11. Korte T, Fuchs M, Arkudas A, Geertz S, Meyer R, Gardiwal A, et al. Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction. Circulation. May 10 2005;111(18):2282–2290
  12. van Eickels M, Patten RD, Aronovitz MJ, Alsheikh-Ali A, Gostyla K, Celestin F, et al. 17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction. J Am Coll Cardiol. Jun 4 2003;41(11):2084–2092
  13. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, et al. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. Feb 2007;292(2):H1187–H1192
  14. Moller JE, Whalley GA, Dini FL, Doughty RN, Gamble GD, Klein AL, et al. Independent prognostic importance of a restrictive left ventricular filling pattern after myocardial infarction: an individual patient meta-analysis: Meta-Analysis Research Group in Echocardiography acute myocardial infarction. Circulation. May 20 2008;117(20):2591–2598
  15. Harpster MH, Bandyopadhyay S, Thomas DP, Ivanov PS, Keele JA, Pineguina N, et al. Earliest changes in the left ventricular transcriptome postmyocardial infarction. Mamm Genome. Jul 2006;17(7):701–715
  16. Kittleson MM, Minhas KM, Irizarry RA, Ye SQ, Edness G, Breton E, et al. Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure. Physiol Genomics. May 11 2005;21(3):299–307
  17. Boheler KR, Volkova M, Morrell C, Garg R, Zhu Y, Margulies K, et al. Sex- and age-dependent human transcriptome variability: implications for chronic heart failure. Proc Natl Acad Sci USA. Mar 4 2003;100(5):2754–2759
  18. Witt H, Schubert C, Jaekel J, Fliegner D, Penkalla A, Tiemann K, et al. Sex-specific pathways in early cardiac response to pressure overload in mice. J Mol Med. Sep 2008;86(9):1013–1024
  19. Weinberg EO, Mirotsou M, Gannon J, Dzau VJ, Lee RT, Pratt RE. Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload. Physiol Genomics. Jan 15 2003;12(2):113–127
  20. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest. Aug 2005;115(8):2108–2118
  21. Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, et al. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. Nov 2007;117(11):3198–3210
  22. van der Laan AM, Piek JJ, van Royen N. Targeting angiogenesis to restore the microcirculation after reperfused MI. Nat Rev Cardiol. Aug 2009;6(8):515–523
  23. Jacobi J, Sydow K, von Degenfeld G, Zhang Y, Dayoub H, Wang B, et al. Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Circulation. Mar 22 2005;111(11):1431–1438
  24. Limaye V. The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology. Endothelium. May-Jun 2008;15(3):101–112
  25. Duan HF, Wang H, Yi J, Liu HJ, Zhang QW, Li LB, et al. Adenoviral gene transfer of sphingosine kinase 1 protects heart against ischemia/reperfusion-induced injury and attenuates its postischemic failure. Hum Gene Ther. Nov 2007;18(11):1119–1128
  26. Lindsey M, Wedin K, Brown MD, Keller C, Evans AJ, Smolen J, et al. Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion. Circulation. May 1 2001;103(17):2181–2187
  27. Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following myocardial infarction. Int J Cardiol. Nov 12 2008;130(2):147–158
  28. Konhilas JP, Leinwand LA. The effects of biological sex and diet on the development of heart failure. Circulation. Dec 4 2007;116(23):2747–2759
  29. Mohandas B, Mehta JL. Lessons from hormone replacement therapy trials for primary prevention of cardiovascular disease. Curr Opin Cardiol. Sep 2007;22(5):434–442
  30. Herrington DM, Klein KP. Randomized clinical trials of hormone replacement therapy for treatment or prevention of cardiovascular disease: a review of the findings. Atherosclerosis. Feb 2003;166(2):203–212
  31. Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA. Apr 4 2007;297(13):1465–1477

PII: S0022-2828(10)00286-5

doi: 10.1016/j.yjmcc.2010.08.002

Journal of Molecular and Cellular Cardiology
Volume 49, Issue 5 , Pages 801-811 , November 2010