Journal of Molecular and Cellular Cardiology
Volume 49, Issue 4 , Pages 598-605 , October 2010

Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction

  • Karsten grosse Kreymborg

      Affiliations

    • University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Germany
    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • Pediatric Heart Center, University of Giessen and Marburg, Germany
    • ,
  • Shizuka Uchida

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Pascal Gellert

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • André Schneider

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Thomas Boettger

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Robert Voswinckel

      Affiliations

    • University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Germany
    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Astrid Wietelmann

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Marten Szibor

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Norbert Weissmann

      Affiliations

    • University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Germany
    • ,
  • Ardeschir Hossein Ghofrani

      Affiliations

    • University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Germany
    • ,
  • Ralph Schermuly

      Affiliations

    • University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Germany
    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Dietmar Schranz

      Affiliations

    • Pediatric Heart Center, University of Giessen and Marburg, Germany
    • ,
  • Werner Seeger

      Affiliations

    • University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Germany
    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • ,
  • Thomas Braun

      Affiliations

    • Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
    • Corresponding Author InformationCorresponding author. Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 1, 61231 Bad Nauheim, Germany. Tel.: +49 6032 705 1102; fax: +49 6032 705 1104.

Received 3 January 2010 ,Revised 6 July 2010 ,Accepted 20 July 2010.

References 

  1. Frey N, Katus HA, Olson EN, Hill JA. Hypertrophy of the heart: a new therapeutic target?. Circulation. 2004;109(13):1580–1589
  2. Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, et al. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation. 2006;114(17):1883–1891
  3. Greyson CR. Pathophysiology of right ventricular failure. Crit Care Med. 2008;36(1 Suppl):S57–S65
  4. Rutledge JM, Nihill MR, Fraser CD, Smith OE, McMahon CJ, Bezold LI. Outcome of 121 patients with congenitally corrected transposition of the great arteries. Pediatr Cardiol. 2002;23(2):137–145
  5. Rockman HA, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, et al. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci USA. 1994;91(7):2694–2698
  6. Gautier L, Cope L, Bolstad BM, Irizarry RA. affy–analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 2004;20(3):307–315
  7. Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004;3(1):[Article 3]
  8. Ihaka R, Gentleman R. R: a language for data analysis and graphics. J Comput Graph Stat. 1996;5:299–314
  9. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 2003;31(4):e15
  10. PGA. Genomics of Cardiovascular Development, Adaptation, and Remodeling. NHLBI Program for Genomic Applications, Harvard Medical School (http://www.cardiogenomics.org - January 2, 2008).
  11. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 1998;95(25):14863–14868
  12. Eisen Lab Software [http://rana.lbl.gov/EisenSoftware.htm].
  13. Uchida S, Nishida Y, Satou K, Muta S, Tashiro K, Kuhara S. Detection and normalization of biases present in spotted cDNA microarray data: a composite method addressing dye, intensity-dependent, spatially-dependent, and print-order biases. DNA Res. 2005;12(1):1–7
  14. Ryan T, Petrovic O, Dillon JC, Feigenbaum H, Conley MJ, Armstrong WF. An echocardiographic index for separation of right ventricular volume and pressure overload. J Am Coll Cardiol. 1985;5(4):918–927
  15. Urashima T, Zhao M, Wagner R, Fajardo G, Farahani S, Quertermous T, et al. Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis. Am J Physiol Heart Circ Physiol. 2008;295(3):H1351–H1368
  16. Mirotsou M, Dzau VJ, Pratt RE, Weinberg EO. Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy. Physiol Genomics. 2006;27(1):86–94
  17. Bogaard HJ, Abe K, Vonk Noordegraaf A, Voelkel NF. The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest. 2009;135(3):794–804
  18. Tabibiazar R, Wagner RA, Liao A, Quertermous T. Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Circ Res. 2003;93(12):1193–1201
  19. Seki S, Kawaguchi Y, Chiba K, Mikami Y, Kizawa H, Oya T, et al. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet. 2005;37(6):607–612
  20. Hayes CJ, Gersony WM, Driscoll DJ, Keane JF, Kidd L, O'Fallon WM, et al. Second natural history study of congenital heart defects. Results of treatment of patients with pulmonary valvar stenosis. Circulation. 1993;87(2 Suppl):I28–I37
  21. Rhodes J, Dave A, Pulling MC, Geggel RL, Marx GR, Fulton DR, et al. Effect of pulmonary artery stenoses on the cardiopulmonary response to exercise following repair of tetralogy of Fallot. Am J Cardiol. 1998;81(10):1217–1219
  22. Belenkie I, Smith ER, Tyberg JV. Ventricular interaction: from bench to bedside. Ann Med. 2001;33(4):236–241
  23. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol. 2004;287(4):L656–L664
  24. Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J. 2001;15(2):427–438
  25. Werchan PM, Summer WR, Gerdes AM, McDonough KH. Right ventricular performance after monocrotaline-induced pulmonary hypertension. Am J Physiol. 1989;256(5 Pt 2):H1328–H1336
  26. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, et al. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell. 2003;5(6):877–889
  27. Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, et al. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet. 2007;8(Suppl 1):S3
  28. Gould DB, Phalan FC, van Mil SE, Sundberg JP, Vahedi K, Massin P, et al. Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med. 2006;354(14):1489–1496
  29. Brancaccio M, Hirsch E, Notte A, Selvetella G, Lembo G, Tarone G. Integrin signaling: the tug-of-war in heart hypertrophy. Cardiovasc Res. 2006;70(3):422–433
  30. Unterseher F, Hefele JA, Giehl K, De Robertis EM, Wedlich D, Schambony A. Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK. EMBO J. 2004;23(16):3259–3269
  31. Bereczki E, Santha M. The role of biglycan in the heart. Connect Tissue Res. 2008;49(3):129–132
  32. Liu Q, Yu L, Gao J, Fu Q, Zhang J, Zhang P, et al. Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. Mol Biol Rep. 2000;27(4):241–246
  33. Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 2008;93(5):613–621
  34. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, et al. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 2004;94(1):110–118
  35. Harris CD, Ermak G, Davies KJ. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol Life Sci. 2005;62(21):2477–2486
  36. Mori M, Nakajima M, Mikami Y, Seki S, Takigawa M, Kubo T, et al. Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. Biochem Biophys Res Commun. 2006;341(1):121–127

PII: S0022-2828(10)00279-8

doi: 10.1016/j.yjmcc.2010.07.014

Journal of Molecular and Cellular Cardiology
Volume 49, Issue 4 , Pages 598-605 , October 2010

Article Tools

* Image Usage & Resolution