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Journal of Molecular and Cellular Cardiology
Volume 49, Issue 4
, Pages 543-553
, October 2010
The pathophysiological mechanism underlying Brugada syndrome: Depolarization versus repolarization
References
- . Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol. 1992;20:1391–1396
- Brugada syndrome: report of the second consensus conference. Heart Rhythm. 2005;2:429–440
- Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome. Circulation. 2005;111:257–263
- Natural history of Brugada syndrome: insights for risk stratification and management. Circulation. 2002;105:1342–1347
- . Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with brugada syndrome: multicenter study in Japan. J Cardiovasc Electrophysiol. 2007;18:1244–1251
- Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org). Heart Rhythm. 2009;6:1335–1341
- . Brugada syndrome. Pacing Clin Electrophysiol. 2006;29:1130–1159
- . Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?. Cardiovasc Res. 2005;67:367–378
- . Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation. 1999;100:1660–1666
- Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death. J Am Coll Cardiol. 1996;27:443–448
- Increased dispersion of repolarization time determined by monophasic action potentials in two patients with familial idiopathic ventricular fibrillation. J Cardiovasc Electrophysiol. 1998;9:74–83
- . Delay in right ventricular activation contributes to Brugada syndrome. Circulation. 2004;109:1272–1277
- Idiopathic ventricular fibrillation induced with vagal activity in patients without obvious heart disease. Circulation. 1997;95:2277–2285
- Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation. 2005;112:2769–2777
- Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study. Circ Arrhythm Electrophysiol. 2008;1:379–386
- Epicardial electrogram of the right ventricular outflow tract in patients with the Brugada syndrome: using the epicardial lead. J Am Coll Cardiol. 2002;39:1992–1995
- Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome: using body surface signal-averaged electrocardiography and body surface maps. J Cardiovasc Electrophysiol. 2004;15:870–876
- Body surface potential mapping in patients with Brugada syndrome: right precordial ST segment variations and reverse changes in left precordial leads. Cardiovasc Res. 2002;54:58–66
- Local depolarization abnormalities are the dominant pathophysiologic mechanism for the type-1 ECG in Brugada syndrome. A study of electrocardiograms, vectorcardiograms and body surface potential maps during ajmaline provocation. J Am Coll Cardiol. 2010;55:789–797
- The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol. Eur Heart J. 2003;24:1104–1112
- . Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome. J Cardiovasc Electrophysiol. 2006;17:857–864
- Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome. Heart Rhythm. 2005;2:254–260
- Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation. 2000;101:510–515
- Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000;11:1320–1329
- Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998;392:293–296
- Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome. Cardiovasc Res. 1999;44:507–517
- . ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: insight into the mechanism of Brugada syndrome. J Cardiovasc Electrophysiol. 1999;10:214–218
- Subepicardial phase-0 block and discontinuous transmural conduction underlie right-precordial ST-segment elevation by a SCN5A loss-of-function mutation. Am J Physiol Heart Circ Physiol. 2008;295:H48–H58
- Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. Circulation. 2005;112:3680–3687
- Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. Circulation. 2008;118:1697–1704
- Electrocardiographic changes evoked by ajmaline in chronic Chagas' disease with manifest myocarditis. Am J Cardiol. 1982;49:14–20
- Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system. Circ Res. 2003;92:159–168
- Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation. 2005;112:1927–1935
- Slow conduction in the infarcted human heart. 'Zigzag' course of activation. Circulation. 1993;88:915–926
- Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases. Eur Heart J. 2009;30:487–496
- SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome. Circ Cardiovasc Genet. 2009;2:552–557
- . Genetic control of sodium channel function. Cardiovasc Res. 2003;57:961–973
- . Fever increases the risk for cardiac arrest in the Brugada syndrome. Ann Intern Med. 2008;149:216–218
- . Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T wave. Circulation. 1987;75:379–386
- Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. Heart Rhythm. 2010;7:238–248
- . Characterization of impulse propagation at the microscopic level across geometrically defined expansions of excitable tissue: multiple site optical recording of transmembrane voltage (MSORTV) in patterned growth heart cell cultures. J Gen Physiol. 1994;104:287–309
- . The Brugada syndrome: clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol. 1999;33:5–15
- . Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol. 1996;27:1061–1070
- Brugada syndrome: a decade of progress. Circ Res. 2002;91:1114–1118
- The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome. J Am Coll Cardiol. 2002;40:330–334
- Cellular basis for trigger and maintenance of ventricular fibrillation in the brugada syndrome model high-resolution optical mapping study. J Am Coll Cardiol. 2006;47:2074–2085
- Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation. 2002;106:2004–2011
- . Role of sodium and calcium channel block in unmasking the Brugada syndrome. Heart Rhythm. 2004;1:210–217
- Repolarization heterogeneity in the right ventricular outflow tract: correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model. Heart Rhythm. 2008;5:725–733
- . Mechanisms of disease: current understanding and future challenges in Brugada syndrome. Nat Clin Pract Cardiovasc Med. 2005;2:408–414
- . Sodium channel variants in heart disease: expanding horizons. J Cardiovasc Electrophysiol. 2006;17(Suppl 1):S151–S157
- Absence of pathognomonic or inflammatory patterns in cardiac biopsies from patients with Brugada syndrome. Circ Arrhythm Electrophysiol. 2009;2:16–23
- . Late potentials and the Brugada syndrome. J Am Coll Cardiol. 2002;39:1996–1999
- Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhythmias in Brugada syndrome. J Cardiovasc Electrophysiol. 2002;13:742–749
- . Brugada. Am J Crit Care. 2001;10:360–364
- . Noninvasive risk stratification of subjects with a Brugada-type electrocardiogram and no history of cardiac arrest. Ann Noninvasive Electrocardiol. 2005;10:396–403
- . Ventricular late potential in patients with apparently normal electrocardiogram; predictor of Brugada syndrome. Pacing Clin Electrophysiol. 2010;33(3):266–273
- Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome. Eur Heart J. 2001;22:1032–1041
- . Brugada syndrome: historical perspectives and observations. Eur Heart J. 2002;23:676–678
- . Syncope due to Brugada syndrome in a young athlete. Br J Sports Med. 2006;41:180–181
- . Electrocardiographic changes during stress test in a patient with "Brugada syndrome". Arch Cardiol Méx. 2001;71:66–72
- . Spatial and temporal heterogeneity of depolarization and repolarization may complicate implantable cardioverter defibrillator therapy in Brugada syndrome. J Cardiovasc Electrophysiol. 2000;11:516–521
- . Exercise-induced ECG changes in Brugada syndrome. Circ Arrhythm Electrophysiol. 2009;2:531–539
- . Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation. 2004;110:1731–1737
- . Pharmacologic approach to therapy of Brugada syndrome: quinidine as an alternative to ICD therapy?. In: Antzelevitch C, Brugada P, Brugada J, Brugada R editor. The Brugada syndrome: from bench to bedside. Oxford: Blackwell Futura; 2004;p. 202–211
- Elimination of late potentials by quinidine in a patient with Brugada syndrome. J Electrocardiol. 2006;39:63–66
- . Cellular basis for ST-segment changes observed during ischemia. J Electrocardiol. 2003;36(Suppl):1–5
- . Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences. J Electrocardiol. 2005;38:14–17
- . R wave amplitude in ischemia, injury, and infarction. Plenary address. J Electrocardiol. 1996;29(Suppl):171–178
- . Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of epicardium to electrical depression. Am J Physiol Heart Circ Physiol. 2008;295:H154–H162
- . A wedge is not a heart. Heart Rhythm. 2007;4:1116–1119
- Electrophysiologic characteristics and implications of induced ventricular fibrillation in symptomatic patients with Brugada syndrome. J Am Coll Cardiol. 2002;39:1799–1805
- Risk stratification for asymptomatic patients with Brugada syndrome. Circ J. 2003;67:312–316
- Spontaneous alternans in Brugada ECG morphology. J Interv Card Electrophysiol. 2006;15:131–134
- ST segment and T wave alternans in a patient with Brugada syndrome. Pacing Clin Electrophysiol. 2000;23:413–415
- Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2008;19:56–61
- Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome. Heart Rhythm. 2009;6:487–492
- A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc Res. Mar 1 2009;81(4):686–694
- . Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome. Circ Arrhythm Electrophysiol. 2008;1:209–218
- . Diagnostic and prognostic value of augmented ST-segment elevation at exercise testing in patients with Brugada syndrome. Circulation. 2008;118(Suppl 2):S674
- . Cellular mechanism and arrhythmogenic potential of T-wave alternans in the Brugada syndrome. J Cardiovasc Electrophysiol. Mar 2008;19(3):301–308
- In: Antzelevitch C editors. The Brugada syndrome. From bench to bedside. Malden, MA: Blackwell, Futura; 2005;
☆ Supported by grant HL47678 (C.A.) from NHLBI, and New York State and Florida Grand Lodges of Free and Accepted Masons.
PII: S0022-2828(10)00276-2
doi: 10.1016/j.yjmcc.2010.07.012
© 2010 Elsevier Ltd. All rights reserved.
« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 49, Issue 4
, Pages 543-553
, October 2010
