Journal of Molecular and Cellular Cardiology
Volume 49, Issue 4 , Pages 543-553, October 2010

The pathophysiological mechanism underlying Brugada syndrome:☆

Depolarization versus repolarization

  • Arthur A.M. Wilde

      Affiliations

    • Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    • ,
  • Pieter G. Postema

      Affiliations

    • Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    • ,
  • José M. Di Diego

      Affiliations

    • Masonic Medical Research Laboratory, Utica, NY, USA
    • ,
  • Sami Viskin

      Affiliations

    • Department of Cardiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
    • ,
  • Hiroshi Morita

      Affiliations

    • Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    • ,
  • Jeffrey M. Fish

      Affiliations

    • Masonic Medical Research Laboratory, Utica, NY, USA
    • ,
  • Charles Antzelevitch

      Affiliations

    • Masonic Medical Research Laboratory, Utica, NY, USA
    • Corresponding Author InformationCorresponding author. Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA. Tel.: +1 315 735 2217; fax: +1 315 735 5648.

Received 4 June 2010; received in revised form 13 July 2010; accepted 19 July 2010. published online 26 July 2010.

Abstract 

This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.

Keywords: Brugada syndrome, Depolarization versus repolarization

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☆ Supported by grant HL47678 (C.A.) from NHLBI, and New York State and Florida Grand Lodges of Free and Accepted Masons.

PII: S0022-2828(10)00276-2

doi:10.1016/j.yjmcc.2010.07.012

Journal of Molecular and Cellular Cardiology
Volume 49, Issue 4 , Pages 543-553, October 2010

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