Journal of Molecular and Cellular Cardiology
Volume 48, Issue 6 , Pages 1329-1334 , June 2010

Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes

  • Mirko Voelkers

      Affiliations

    • Department of Internal Medicine III, Laboratory for Molecular and Translational Cardiology, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding authors. M. Voelkers is to be contacted at the Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany. P. Most, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
    • ,
  • Mareen Salz

      Affiliations

    • Department of Internal Medicine III, Laboratory for Molecular and Translational Cardiology, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    • ,
  • Nicole Herzog

      Affiliations

    • Department of Internal Medicine III, Laboratory for Molecular and Translational Cardiology, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    • ,
  • Derk Frank

      Affiliations

    • Department of Internal Medicine III, Laboratory for Molecular and Translational Cardiology, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    • ,
  • Nima Dolatabadi

      Affiliations

    • San Diego Heart Institute, San Diego State University, San Diego, CA 92182, USA
    • ,
  • Norbert Frey

      Affiliations

    • Department of Cardiology and Angiology, University of Kiel, Schittenhelmstraβe 12, 24105 Kiel, Germany
    • ,
  • Natalie Gude

      Affiliations

    • San Diego Heart Institute, San Diego State University, San Diego, CA 92182, USA
    • ,
  • Oliver Friedrich

      Affiliations

    • Institute of Physiology and Pathophysiology, Medical Biophysics, INF 326, University of Heidelberg, 69120 Heidelberg, Germany
    • ,
  • Walter J. Koch

      Affiliations

    • Center for Translational Medicine, Laboratory for Cardiac Stem Cell and Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    • ,
  • Hugo A. Katus

      Affiliations

    • Department of Internal Medicine III, Laboratory for Molecular and Translational Cardiology, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    • ,
  • Mark A. Sussman

      Affiliations

    • San Diego Heart Institute, San Diego State University, San Diego, CA 92182, USA
    • ,
  • Patrick Most

      Affiliations

    • Department of Internal Medicine III, Laboratory for Molecular and Translational Cardiology, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    • Center for Translational Medicine, Laboratory for Cardiac Stem Cell and Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    • Corresponding Author InformationCorresponding authors. M. Voelkers is to be contacted at the Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany. P. Most, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Received 9 December 2009 ,Revised 23 January 2010 ,Accepted 28 January 2010.

References 

  1. Berridge MJ. Cardiac calcium signalling. Biochem Soc Trans. Oct 2003;31(Pt 5):930–933
  2. Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol. 2003;65:45–79
  3. Cahalan MD. STIMulating store-operated Ca(2+) entry. Nat Cell Biol. Jun 2009;11(6):669–677
  4. Ohba T, Watanabe H, Murakami M, Sato T, Ono K, Ito H. Essential role of STIM1 in the development of cardiomyocyte hypertrophy. Biochem Biophys Res Commun. Nov 6 2009;389(1):172–176
  5. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature. Sep 14 2006;443(7108):230–233
  6. Most P, Boerries M, Eicher C, Schweda C, Ehlermann P, Pleger ST, et al. Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2). J Biol Chem. Nov 28 2003;278(48):48404–48412
  7. Most P, Pleger ST, Volkers M, Heidt B, Boerries M, Weichenhan D, et al. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. Dec 2004;114(11):1550–1563
  8. Hunton DL, Lucchesi PA, Pang Y, Cheng X, Dell'Italia LJ, Marchase RB. Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytes. J Biol Chem. Apr 19 2002;277(16):14266–14273
  9. Hunton DL, Zou L, Pang Y, Marchase RB. Adult rat cardiomyocytes exhibit capacitative calcium entry. Am J Physiol Heart Circ Physiol. Mar 2004;286(3):H1124–H1132
  10. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, et al. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. Mar 2006;116(3):675–682
  11. Nishida M, Kurose H. Roles of TRP channels in the development of cardiac hypertrophy. Naunyn Schmiedebergs Arch Pharmacol. Oct 2008;378(4):395–406
  12. Nakayama H, Wilkin BJ, Bodi I, Molkentin JD. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J. Aug 2006;20(10):1660–1670
  13. Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, et al. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res. Nov 6 2009;105(10):1023–1030
  14. Stiber J, Hawkins A, Zhang ZS, Wang S, Burch J, Graham V, et al. STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol. Jun 2008;10(6):688–697
  15. Lee KP, Yuan JP, Hong JH, Worley PF, Muallem S. An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett. Nov 27 2009;
  16. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. May 31 1990;322(22):1561–1566
  17. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, et al. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. Sep 2008;28(17):5209–5222

PII: S0022-2828(10)00033-7

doi: 10.1016/j.yjmcc.2010.01.020

Journal of Molecular and Cellular Cardiology
Volume 48, Issue 6 , Pages 1329-1334 , June 2010

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