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Journal of Molecular and Cellular Cardiology
Volume 47, Issue 6
, Pages 752-760
, December 2009
Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity
References
- . A systematic review of interventions to increase awareness, knowledge, and folic acid consumption before and during pregnancy. Am. J. Health Promot. 2008;22:237–245
- . Importance of folate-homocysteine homeostasis during early embryonic development. Clin. Chem. Lab. Med. 2007;45:1717–1727
- . The treatment of Hyperhomocysteinemia. Annu. Rev. Med. 2008;
- . Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am. J. Pathol. 1969;56:111–128
- . Homocysteine, vitamins, and vascular disease prevention. Am. J. Clin. Nutr. 2007;86:1563S–1568S
- . Homocysteine and atherothrombosis. N. Engl. J. Med. 1998;338:1042–1050
- . Key references: homocysteine and atherothrombotic vascular disease. J. Thromb. Thrombolysis. 2000;9:125–126
- Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study. Arterioscler. Thromb. Vasc. Biol. 2001;21:2080–2085
- . Homocystinuria. Reduced folate levels during pyridoxine treatment. Arch. Dis. Child. 1973;48:58–62
- . The pathogenesis of coronary artery disease. A possible role for methionine metabolism. J. Clin. Invest. 1976;57:1079–1082
- . Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2002;22:34–41
- . Influence of hyperhomocysteinemia on the cellular redox state—impact on homocysteine-induced endothelial dysfunction. Clin. Chem. Lab. Med. 2003;41:1455–1461
- . Homocysteine trials—clear outcomes for complex reasons. N. Engl. J. Med. 2006;354:1629–1632
- Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA. 2007;298:1163–1170
- . Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann. Intern. Med. 2007;146:761–767
- . Vitamin Intervention For Stroke Prevention trial: an efficacy analysis. Stroke. 2005;36:2404–2409
- Homocysteine lowering with folic acid and B vitamins in vascular disease. N. Engl. J. Med. 2006;354:1567–1577
- . B vitamins for the prevention of vascular disease: insufficient evidence to justify treatment. JAMA. 2007;298:1212–1214
- Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet. 2007;369:1876–1882
- . Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296:2720–2726
- . Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ. 2006;333:1114–1117
- . Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. Am. J. Physiol., Heart Circ. Physiol. 2008;294:H1971–H1977
- . Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 2005;102:9056–9061
- . Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 2000;87:840–844
- . Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes. 2007;56:118–126
- . Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia–reperfusion. Am. J. Nephrol. 2008;28:692–700
- . Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion. Am. J. Med. Sci. 2008;335:177–187
- Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am. J. Physiol., Heart Circ. Physiol. 2009;297:H331–H339
- Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones. J. Neurochem. 2002;82:1300–1310
- . Rapid method for the determination of total 5-methyltetrahydrofolate in blood by liquid chromatography with fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002;766:331–337
- 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation. 2006;114:1193–1201
- . A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J. Nutr. 2008;138:2323–2327
- . Assay of dihydrofolate reductase activity by monitoring tetrahydrofolate using high-performance liquid chromatography with electrochemical detection. Anal. Biochem. 1999;272:143–148
- . Purification and characterization of beef liver dihydrofolate reductase. Arch. Biochem. Biophys. 1976;172:289–300
- . Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines. Arch. Biochem. Biophys. 1985;236:681–690
- . The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol. Sci. 2003;24:471–478
- Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arterioscler. Thromb. Vasc. Biol. 2001;21:1196–1202
- Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation. 2007;115:2262–2270
- . Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation. 2000;102:2479–2483
- . Folic acid in endothelial function in familial hypercholesterolemia. Circulation. 2000;102:E92
PII: S0022-2828(09)00317-4
doi: 10.1016/j.yjmcc.2009.07.025
© 2009 Elsevier Inc. All rights reserved.
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Journal of Molecular and Cellular Cardiology
Volume 47, Issue 6
, Pages 752-760
, December 2009
