Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 264-274 , August 2009

Rac1 mediates sex difference in cardiac tumor necrosis factor-α expression via NADPH oxidase–ERK1/2/p38 MAPK pathway in endotoxemia

  • Huaqing Zhu

      Affiliations

    • Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada N6A 4G5
    • Department of Medicine, University of Western Ontario, London, Ontario, Canada N6A 4G5
    • Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, China
    • ,
  • Limei Shan

      Affiliations

    • Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada N6A 4G5
    • Department of Medicine, University of Western Ontario, London, Ontario, Canada N6A 4G5
    • ,
  • Tianqing Peng

      Affiliations

    • Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada N6A 4G5
    • Department of Medicine, University of Western Ontario, London, Ontario, Canada N6A 4G5
    • Department of Pathology, University of Western Ontario, London, Ontario, Canada N6A 4G5
    • Corresponding Author InformationCorresponding author. Critical Illness Research, Lawson Health Research Institute, VRL 6th Floor, A6-140, 800 Commissioners Road, London, Ontario, Canada N6A 4G5. Tel.: +1 519 685 8300x55441; fax: +1 519 685 8341.

Received 30 January 2009 ,Revised 19 April 2009 ,Accepted 8 May 2009.

References 

  1. Meldrum DR. Tumor necrosis factor in the heart. Am. J. Physiol. 1998;274:R577–R595
  2. Grandel U, Fink L, Blum A, Heep M, Buerke M, Kraemer HJ, et al. Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production. Circulation. 2000;102:2758–2764
  3. Oral H, Dorn GW, Mann DL. Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. J. Biol. Chem. 1997;272:4836–4842
  4. Bozkurt B, Kribbs SB, Clubb FJ, Michael LH, Didenko VV, Hornsby PJ, et al. Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circulation. 1998;97:1382–1391
  5. Peng T, Lu X, Lei M, Moe GW, Feng Q. Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc. Res. 2003;59:893–900
  6. Neuzil J, Widen C, Gellert N, Swettenham E, Zobalova R, Dong LF, et al. Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia–reperfusion injury. Redox. Rep. 2007;12:148–162
  7. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, et al. The cardiovascular response of normal humans to the administration of endotoxin. N. Engl. J. Med. 1989;321:280–287
  8. Hoebe K, Jiang Z, Georgel P, Tabeta K, Janssen E, Du X, et al. TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy. Curr. Pharm. Des. 2006;12:4123–4134
  9. Peng T, Lu X, Feng Q. Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Circulation. 2005;111:1637–1644
  10. Babior BM, Lambeth JD, Nauseef W. The neutrophil NADPH oxidase. Arch. Biochem. Biophys. 2002;397:342–344
  11. Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCray PB, et al. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J. Biol. Chem. 2001;276:30188–30198
  12. Schroder J, Kahlke V, Staubach KH, Zabel P, Stuber F. Gender differences in human sepsis. Arch. Surg. 1998;133:1200–1205
  13. Horton JW, White DJ, Maass DL. Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma. Am. J. Physiol. Heart Circ. Physiol. 2004;286:HH13–H202
  14. Deshpande R, Khalili H, Pergolizzi RG, Michael SD, Chang MD. Estradiol down-regulates LPS-induced cytokine production and NF-kB activation in murine macrophages. Am. J. Reprod. Immunol. 1997;38:46–54
  15. Moeinpour F, Choudhry MA, Kawasaki T, Timares L, Schwacha MG, Bland KI, et al. 17 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage. Mol. Immunol. 2007;44:3317–3323
  16. Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J. Clin. Invest. 1999;104:1703–1714
  17. Shen E, Li Y, Li Y, Feng Q, Arnold JMO, Peng T. Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes. 2009;Under revision
  18. Li Y, Arnold JMO, Pampillo M, Babwah AV, Peng T. Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation. Free Radic. Biol. Med. 2009;46:51–61
  19. Layland J, Cave AC, Warren C, Grieve DJ, Sparks E, Kentish JC, et al. Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J. 2005;19:1137–1139
  20. Raafat AM, Hofseth LJ, Li S, Bennett JM, Haslam SZ. A mouse model to study the effects of hormone replacement therapy on normal mammary gland during menopause: enhanced proliferative response to estrogen in late postmenopausal mice. Endocrinology. 1999;140:2570–2580
  21. Ebrahimiana T, Heb Y, Schiffrina EL, Touyzb RM. Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice. J. Hypertens. 2007;25:1263–1271
  22. van Eickels M, Grohe C, Cleutjens JP, Janssen BJ, Wellens HJ, Doevendans PA. 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation. 2001;104:1419–1423
  23. Cavasin MA, Sankey SS, Yu AL, Menon S, Yang XP. Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2003;284:H1560–H1569
  24. Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW, et al. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation. 2007;115:3197–3204
  25. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT. Aldosterone-induced inflammation in the rat heart: role of oxidative stress. Am. J. Pathol. 2002;161:1773–1781
  26. Satoh M, Ogita H, Takeshita K, Mukai Y, Kwiatkowski DJ, Liao JK. Requirement of Rac1 in the development of cardiac hypertrophy. Proc. Natl. Acad. Sci. U. S. A. 2006;103:7432–7437
  27. Laufs U, Adam O, Strehlow K, Wassmann S, Konkol C, Laufs K, et al. Down-regulation of Rac-1 GTPase by estrogen. J. Biol. Chem. 2003;278:5956–5962
  28. Sumi D, Hayashi T, Matsui-Hirai H, Jacobs AT, Ignarro LJ, Iguchi A. 17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells. Biochim. Biophys. Acta. 2003;1640:113–118
  29. Wang M, Tsai BM, Reiger KM, Brown JW, Meldrum DR. 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J. Mol. Cell. Cardiol. 2006;40:205–212
  30. Kim JK, Pedram A, Razandi M, Levin ER. Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J. Biol. Chem. 2006;281:6760–6767
  31. Angele MK, Nitsch S, Knoferl MW, Ayala A, Angele P, Schildberg FW, et al. Sex-specific p38 MAP kinase activation following trauma-hemorrhage: involvement of testosterone and estradiol. Am. J. Physiol. Endocrinol. Metab. 2003;285:EE96–E189
  32. Xin HB, Senbonmatsu T, Cheng DS, Wang YX, Copello JA, Ji GJ, et al. Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature. 2002;416:334–338

PII: S0022-2828(09)00191-6

doi: 10.1016/j.yjmcc.2009.05.002

Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 264-274 , August 2009

Article Tools

* Image Usage & Resolution