Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 171-173 , August 2009

Keeping the beat: Life without SERCA — Is it possible?

  • Andrew W. Trafford

      Affiliations

    • Unit of Cardiac Physiology, University of Manchester, 3.08 Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 161 275 7969; fax: +44 161 275 2703.
    • ,
  • W. Jonathan Lederer

      Affiliations

    • Institute of Molecular Cardiology, Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 W. Lombard Street, Baltimore, MD 21201, USA
    • ,
  • Eric A. Sobie

      Affiliations

    • Institute of Molecular Cardiology, Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 W. Lombard Street, Baltimore, MD 21201, USA
    • Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA

Received 8 May 2009 ,Accepted 11 May 2009.

References 

  1. Trafford AW, Díaz ME, O'Neill SC, Eisner DA. Integrative analysis of calcium signalling in cardiac muscle. Front. Biosci. 2002;6:D53–D64
  2. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. 2 ed. Dordrecht/Boston/London: Kluwer Academic Publishers; 2001;
  3. Cheng H, Lederer WJ, Cannell MB. Calcium sparks: elementary events underlying excitation–contraction coupling in heart muscle. Science. 1993;262:740–744
  4. López-López JR, Shacklock PS, Balke CW, Wier WG. Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science. 1995;268:1042–1045
  5. Cannell MB, Cheng H, Lederer WJ. The control of calcium release in heart muscle. Science. 1995;268:1045–1049
  6. Negretti N, O'Neill SC, Eisner DA. The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes. Cardiovasc. Res. 1993;27:1826–1830
  7. Bassani JWM, Bassani RA, Bers DM. Relaxation in rabbit and rat cardiac cells: species-dependant differences in cellular mechanisms. J. Physiol. (Lond). 1994;476:279–293
  8. Díaz ME, Graham HK, Trafford AW. Enhanced sarcolemmal Ca2+ efflux reduces sarcoplasmic reticulum Ca2+ content and systolic Ca2+ in cardiac hypertrophy. Cardiovasc. Res. 2004;62:538–547
  9. O'Rourke B, Kass DA, Tomaselli GF, Kaab S, Tunin R, Marban E. Mechanisms of altered excitation–contraction coupling in canine tachycardia-induced heart failure, I Experimental studies. Circ. Res. 1999;84:562–570
  10. Pieske B, Maier LS, Bers DM, Hasenfuss G. Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium. Circ. Res. 1999;85:38–46
  11. Del Monte F, Harding SE, Schmidt U, Matsui T, Kang ZB, Dec GW, et al. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation. 1999;100:2308–2311
  12. Andersson KV, Birkeland JAK, Finsen AV, Louch WE, Sjaastad I, Wang Y, et al. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol. 2009;47:180–187
  13. Bassani JWM, Yuan W, Bers DM. Fractional SR Ca2+ release is regulated by trigger Ca2+ and SR Ca2+ content in cardiac myocytes. Am. J. Physiol. 1995;268:C1313–C1329
  14. Trafford AW, Díaz ME, Eisner DA. Coordinated control of cell Ca2+ loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca2+ current. Circ. Res. 2001;88:195–201
  15. Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, et al. Functional Adult Myocardium in the absence of Na+–Ca2+ exchange: cardiac specific knockout of NCX1. Circ. Res. 2004;95:604–611
  16. Guo W, Jung WE, Marionneau C, Aimond F, Xu H, Yamada KA, et al. Targeted deletion of Kv4.2 eliminates Ito,f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ. Res. 2005;97:1342–1350
  17. Lakatta EG, DiFrancesco D. What keeps us ticking: a funny current, a calcium clock, or both?. J Mol Cell Cardiol. 2009;47:157–170
  18. Díaz ME, Trafford AW, O'Neill SC, Eisner DA. A measurable reduction of SR Ca2+ content follows spontaneous Ca2+ release in rat ventricular myocytes. Pflügers Archiv. 1997;434:852–854
  19. Cheng H, Lederer WJ. Calcium Sparks Physiol. Rev. 2008;88:1491–1545
  20. Oceandy D, Cartwright EJ, Emerson M, Prehar S, Baudoin FM, Zi M, et al. Neuronal Nitric Oxide Synthase Signaling in the Heart Is Regulated by the Sarcolemmal Calcium Pump 4b. Circulation. 2007;115:483–492
  21. Periasamy M, Reed TD, Liu LH, Ji Y, Loukianov E, Paul RJ, et al. Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J. Biol. Chem. 1999;274:2556–2562
  22. Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL. Computer model of action potential of mouse ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 2004;287:H1378–H1403
  23. Dibb KM, Eisner DA, Trafford AW. Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+ current and diastolic [Ca2+]i. J. Physiol. (Lond). 2007;585:579–592
  24. Sobie EA, Song LS, Lederer WJ. Restitution of Ca2+ release and vulnerability to arrhythmias. J. Cardiovasc. Electrophysiol. 2006;17(Suppl 1):S64–S70
  25. Dibb KM, Eisner DA, Trafford AW. Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+ current and diastolic [Ca2+]i. J. Physiol. (Lond). 2007;585:579–592
  26. Antoons G, Mubagwa K, Nevelsteen I, Sipido KR. Mechanisms underlying the frequency dependence of contraction and Ca2+ transients in mouse ventricular myocytes. J. Physiol. (Lond). 2002;543:889–898
  27. Snopko RM, Aromolaran AS, Karko KL, Ramos-Franco J, Blatter LA, Mejia-Alvarez R. Cell culture modifies Ca2+ signaling during excitation–contraction coupling in neonate cardiac myocytes. Cell Calcium. 2007;41:13–25
  28. Wang LJ, Sobie EA. Mathematical model of the neonatal mouse ventricular action potential. Am. J. Physiol. Heart Circ. Physiol. 2008;294:H2565–H2575

PII: S0022-2828(09)00190-4

doi: 10.1016/j.yjmcc.2009.05.005

Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 171-173 , August 2009

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