« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2
, Pages 247-255
, August 2009
Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress
References
- . Oxidants, antioxidants and alcohol: implications for skeletal and cardiac muscle. Front. Biosci. 1999 Aug 1;4:e58–e66
- . Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde. Cell Biochem. Funct. 1993 Mar;11(1):45–54
- . Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc. Nutr. Soc. 2004 Feb;63(1):49–63
- . Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Novartis Found. Symp. 2007;285:69–76
- . Determinations of ethanol, acetaldehyde and acetate in blood and urine during alcohol oxidation in man. Alcohol. Alcohol. 1989;24(2):101–108
- . Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes. Cell. Mol. Biol. (Noisy. -le-grand). 1997 Sep;43(6):825–834
- . Influence of chronic alcohol ingestion on acetaldehyde-induced depression of rat cardiac contractile function. Alcohol Alcohol. 2000 Nov;35(6):554–560
- . Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+. Cell. Mol. Biol. (Noisy. -le-grand). 1999 Jun;45(4):453–465
- . Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Alcohol. Clin. Exp. Res. 2003 Jul;27(7):1090–1098
- Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 2002 Apr;282(4):H1216–H1222
- . Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am. J. Physiol. Heart Circ. Physiol. 2008 Sep;295(3):H1206–H1215
- . Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation. 2006 Sep 12;114(11):1159–1168
- . Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun. Diabetologia. 2005 Nov;48(11):2412–2421
- A central role for JNK in obesity and insulin resistance. Nature. 2002 Nov 21;420(6913):333–336
- Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006 Aug 25;313(5790):1137–1140
- . Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. Circulation. 2009;119:1941–1949
- . Rodent models of alcoholism: a review. Alcohol Alcohol. 1989;24(4):299–309
- . Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. J. Biol. Chem. 2004 Mar 19;279(12):11244–11252
- . Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J. Mol. Cell. Cardiol. 2008 Jun;44(6):992–1001
- . Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells. Exp. Neurol. 2007 Jan;203(1):196–204
- The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J. Biol. Chem. 2004 Jan 9;279(2):1513–1525
- . The effect of acute, chronic, and prenatal ethanol exposure on insulin sensitivity. Pharmacol. Ther. 2006 Aug;111(2):346–373
- . Alcohol and the cardiovascular system research challenges and opportunities. J. Am. Coll. Cardiol. 2005 Jun 21;45(12):1916–1924
- Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J. Mol. Cell. Cardiol. 2006 Feb;40(2):283–294
- . Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488–1499
- . Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008 Sep 12;321(5895):1493–1495
- . CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic. Biol. Med. 2001 Dec 15;31(12):1539–1543
- . Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III. Free Radic. Biol. Med. 1999 Oct;27(7–8):891–900
- . Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. Chem. Biol. Interact. 2009 Mar 16;178(1–3):2–7
- . Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes. J. Formos. Med. Assoc. 2002 Nov;101(11):769–774
- . Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption. Clin. Chem. 2002 Jul;48(7):1043–1048
- . The mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is expressed in a tissue-specific manner. Biochem. Biophys. Res. Commun. 1993 May 28;193(1):420–427
- Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism. Cardiovasc. Res. 2003 Aug 1;59(2):390–399
- . Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007 Jul;8(7):519–529
- . ER chaperones in mammalian development and human diseases. FEBS Lett. 2007 Jul 31;581(19):3641–3651
- . Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. Novartis Found. Symp. 2007;286:86–94
- . Endoplasmic reticulum stress exacerbates ischemia–reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. FASEB J. 2007 Mar;21(3):872–884
- . Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch. Diabetologia. 2006 Jun;49(6):1434–1446
PII: S0022-2828(09)00142-4
doi: 10.1016/j.yjmcc.2009.03.017
© 2009 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2
, Pages 247-255
, August 2009
