Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 180-187 , August 2009

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

  • Kristin Brevik Andersson

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway
    • Corresponding Author InformationCorresponding author. Institute for Experimental Medical Research, Ullevaal University Hospital, Kirkeveien 166, NO-0407 Oslo, Norway. Tel.: +47 23 016800; fax: +47 23016799.
    • ,
  • Jon Arne Kro Birkeland

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway
    • ,
  • Alexandra Vanessa Finsen

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway
    • ,
  • William E. Louch

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway
    • ,
  • Ivar Sjaastad

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway
    • Department of Cardiology, Ullevaal University Hospital, 0407 Oslo, Norway
    • ,
  • Yibin Wang

      Affiliations

    • Departments of Anesthesiology, Physiology and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    • ,
  • Ju Chen

      Affiliations

    • School of Medicine, University of California San Diego, La Jolla, CA 92093-0613, USA
    • ,
  • Jeffery D. Molkentin

      Affiliations

    • Department of Pediatrics, University of Cincinnati, Children's Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, OH 45229-3039, USA
    • ,
  • Kenneth R. Chien

      Affiliations

    • Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    • ,
  • Ole M. Sejersted

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway
    • ,
  • Geir Christensen

      Affiliations

    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Center for Heart Failure Research, University of Oslo, 0407 Oslo, Norway

Received 3 February 2009 ,Revised 13 March 2009 ,Accepted 18 March 2009.

References 

  1. MacLennan DH. Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum. J. Biol. Chem. 1970;245:4508–4518
  2. MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat. Rev. Mol. Cell Biol. 2003;4:566–577
  3. Bers DM. Cardiac excitation–contraction coupling. Nature. 2002;415:198–205
  4. Colucci WS, Braunwald E. Pathophysiology of Heart Failure. In:  Zipes DP,  Libby P,  Bonow RO,  Braunwald E editor. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 7th ed. Philadelphia, PA: Elsevier Saunders; 2005;p. 519–520
  5. Periasamy M, Reed TD, Liu LH, Ji Y, Loukianov E, Paul RJ, et al. Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-isoform 2 (SERCA2) gene. J. Biol. Chem. 1999;274:2556–2562
  6. Sohal DS, Nghiem M, Crackower MA, Witt SA, Kimball TR, Tymitz KM, et al. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ. Res. 2001;89:20–25
  7. Liang W, McDonald P, McManus B, van Breemen C, Wang X. Histamine-induced Ca2+ signaling in human valvular myofibroblasts. J. Mol. Cell Cardiol. 2003;35:379–388
  8. Strehler EE, Treiman M. Calcium pumps of plasma membrane and cell interior. Curr. Mol. Med. 2004;4:323–335
  9. Finsen AV, Christensen G, Sjaastad I. Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse. J. Appl. Physiol. 2005;98:680–689
  10. Li L, Chu G, Kranias EG, Bers DM. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. Am. J. Physiol. 1998;274:H1335–H1347
  11. Ver Heyen M, Heymans S, Antoons G, Reed T, Periasamy M, Awede B, et al. Replacement of the muscle-specific sarcoplasmic reticulum Ca2+-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction–relaxation of the heart. Circ. Res. 2001;89:838–846
  12. Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 2006;113:995–1004
  13. Brittsan AG, Ginsburg KS, Chu G, Yatani A, Wolska BM, Schmidt AG, et al. Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circ. Res. 2003;92:769–776
  14. Shannon TR, Ginsburg KS, Bers DM. Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophys. J. 2000;78:334–343
  15. Trafford AW, Diaz ME, Eisner DA. Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current. Circ. Res. 2001;88:195–201
  16. Miriyala J, Nguyen T, Yue DT, Colecraft HM. Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels. Circ. Res. 2008;102:e54–e64
  17. Weber CR, Piacentino V, Ginsburg KS, Houser SR, Bers DM. Na+–Ca2+ exchange current and submembrane [Ca2+] during the cardiac action potential. Circ. Res. 2002;90:182–189
  18. Lines GT, Sande JB, Louch WE, Mørk HK, Grøttum P, Sejersted OM. Contribution of the Na+/Ca2+ exchanger to rapid Ca2+ release in cardiomyocytes. Biophys. J. 2006;91:779–792
  19. Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, et al. Functional adult myocardium in the absence of Na+–Ca2+ exchange: cardiac-specific knockout of NCX1. Circ. Res. 2004;95:604–611
  20. Dobrzynski H, Boyett MR. What do we learn from double Cx40/Cx45-deficient mice about cardiac morphogenetic defects and conduction abnormalities?. J. Mol. Cell Cardiol. 2006;41:774–777
  21. Maltsev VA, Lakatta EG. Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function. Cardiovasc. Res. 2008;77:274–284
  22. Bers DM. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda, MD). 2006;21:380–387
  23. Hamdani N, Kooij V, van Dijk S, Merkus D, Paulus WJ, Remedios CD, et al. Sarcomeric dysfunction in heart failure. Cardiovasc. Res. 2008;77:649–658

PII: S0022-2828(09)00115-1

doi: 10.1016/j.yjmcc.2009.03.013

Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 180-187 , August 2009

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