Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 238-246 , August 2009

Ventricular K+ currents are reduced in mice with elevated levels of serum TNFα

  • Scott A. Grandy
  • ,
  • Céline Fiset

      Affiliations

    • Corresponding Author InformationCorresponding author. Research Center, Montreal Heart Institute, 5000 Bélanger Street, Montréal, Québec, Canada, H1T 1C8. Tel.: +514 376 3330 x3025; fax: +514 376 1355.

Received 13 January 2009 ,Revised 25 February 2009 ,Accepted 26 February 2009.

References 

  1. Prabhu SD. Cytokine-induced modulation of cardiac function. Circ. Res. 2004;95:1140–1153
  2. Chen D, Assad-Kottner C, Orrego C, Torre-Amione G. Cytokines and acute heart failure. Crit. Care. Med. 2008;36:S9–16
  3. McMurray J, Abdullah I, Dargie HJ, Shapiro D. Increased concentrations of tumour necrosis factor in “cachectic” patients with severe chronic heart failure. Br. Heart. J. 1991;66:356–358
  4. Cugno M, Agostoni P, Brunner HR, Gardinali M, Agostoni A, Nussberger J. Plasma bradykinin levels in human chronic congestive heart failure. Clin. Sci. (Lond). 2000;99:461–466
  5. De SK, Devadas K, Notkins AL. Elevated levels of tumor necrosis factor alpha (TNF-alpha) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-alpha. J. Virol. 2002;76:11710–11714
  6. Heckmann A, Waltzinger C, Jolicoeur P, Dreano M, Kosco-Vilbois MH, Sagot Y. IKK2 inhibitor alleviates kidney and wasting diseases in a murine model of human AIDS. Am. J. Pathol. 2004;164:1253–1262
  7. Fernandez-Velasco M, Ruiz-Hurtado G, Hurtado O, Moro MA, Delgado C. TNF-alpha downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation. Am. J. Physiol. Heart Circ. Physiol. 2007;293:H238–H245
  8. Wang J, Wang H, Zhang Y, Gao H, Nattel S, Wang Z. Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator. J. Biol. Chem. 2004;279:13289–13292
  9. Kawada H, Niwano S, Niwano H, Yumoto Y, Wakisaka Y, Yuge M, et al. Tumor necrosis factor-alpha downregulates the voltage gated outward K+ current in cultured neonatal rat cardiomyocytes: a possible cause of electrical remodeling in diseased hearts. Circ. J. 2006;70:605–609
  10. Petkova-Kirova PS, Gursoy E, Mehdi H, McTiernan CF, London B, Salama G. Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-alpha. Am. J. Physiol. Heart Circ. Physiol. 2006;290:H2098–H2107
  11. Nerbonne JM, Nichols CG, Schwarz TL, Escande D. Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here?. Circ. Res. 2001;89:944–956
  12. Kubota T, McTiernan CF, Frye CS, Slawson SE, Lemster BH, Koretsky AP, et al. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circ. Res. 1997;81:627–635
  13. Hatada K, Washizuka T, Horie M, Watanabe H, Yamashita F, Chinushi M, et al. Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway. Biochem. Biophys. Res. Commun. 2006;344:189–193
  14. Franco F, Thomas GD, Giroir B, Bryant D, Bullock MC, Chwialkowski MC, et al. Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation. 1999;99:448–454
  15. Sack MN, Smith RM, Opie LH. Tumor necrosis factor in myocardial hypertrophy and ischaemia—an anti-apoptotic perspective. Cardiovasc. Res. 2000;45:688–695
  16. Herskowitz A. Cardiomyopathy and other symptomatic heart diseases associated with HIV infection. Curr. Opin. Cardiol. 1996;11:325–331
  17. Levy WS, Simon GL, Rios JC, Ross AM. Prevalence of cardiac abnormalities in human immunodeficiency virus infection. Am. J. Cardiol. 1989;63:86–89
  18. Testa M, Yeh M, Lee P, Fanelli R, Loperfido F, Berman JW, et al. Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J. Am. Coll. Cardiol. 1996;28:964–971
  19. Bryant D, Becker L, Richardson J, Shelton J, Franco F, Peshock R, et al. Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation. 1998;97:1375–1381
  20. Trépanier-Boulay V, St-Michel C, Tremblay A, Fiset C. Gender-based differences in cardiac repolarization in mouse ventricle. Circ. Res. 2001;89:437–444
  21. Brouillette J, Grandy SA, Jolicoeur P, Fiset C. Cardiac repolarization is prolonged in CD4C/HIV transgenic mice. J. Mol. Cell. Cardiol. 2007;43:159–167
  22. Fiset C, Clark RB, Shimoni Y, Giles WR. Shal-type channels contribute to the Ca2+-independent transient outward K+ current in rat ventricle. J. Physiol. 1997;500.1:51–64
  23. Trépanier-Boulay V, Lupien MA, St-Michel C, Fiset C. Postnatal development of atrial repolarization in mouse. Cardiovasc. Res. 2004;64:84–90
  24. Brouillette J, Clark RB, Giles WR, Fiset C. Functional properties of currents K+ in adult mouse ventricular myoyctes. J. Physiol. 2004;559:777–798
  25. Grandy SA, Trepanier-Boulay V, Fiset C. Postnatal development has a marked effect on ventricular repolarization in mice. Am. J. Physiol. 2007;293:H2168–H2177
  26. Rivard K, Paradis P, Nemer M, Fiset C. Cardiac-specific overexpression of the human type 1 angiotensin II receptor causes delayed repolarization. Cardiovasc. Res. 2008;78:53–62
  27. Rivard K, Trépanier-Boulay V, Rindt H, Fiset C. Electrical remodeling in a transgenic mouse model of α1B-adrenergic receptor overexpression. Am. J. Physiol. Heart Circ. Physiol. 2009;296(3):H704–H718
  28. Lizotte E, Tremblay A, Allen BG, Fiset C. Isolation and characterization of subcellular protein fractions from mouse heart. Anal. Biochem. 2005;345:47–54
  29. Kuo HC, Cheng CF, Clark RB, Lin JJC, Lin JLC, Hoshijima M, et al A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of Ito and confers susceptibility to ventricular tachycardia. Cell. 2001;107:801–813
  30. Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, et al. Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation. 2003;107:1418–1423
  31. Moe GW, Marin-Garcia J, Konig A, Goldenthal M, Lu X, Feng Q. In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. Am. J. Physiol. Heart Circ. Physiol. 2004;287:H1813–H1820
  32. Kourie JI. Interaction of reactive oxygen species with ion transport mechanisms. Am. J. Physiol. 1998;275:C1–24
  33. Morera FJ, Wolff D, Vergara C. External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle. J. Membr. Biol. 2003;192:65–72
  34. Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc. Res. 2006;71:310–321
  35. Rozanski GJ, Xu Z. Sulfhydryl modulation of K+ channels in rat ventricular myocytes. J. Mol. Cell. Cardiol. 2002;34:1623–1632
  36. London B, Baker LC, Lee JS, Shusterman V, Choi BR, Kubota T, et al. Calcium-dependent arrhythmias in transgenic mice with heart failure. Am. J. Physiol. Heart Circ. Physiol. 2003;284:H431–H441
  37. Krown KA, Yasui K, Brooker MJ, Dubin AE, Nguyen C, Harris GL, et al. Alpha receptor expression in rat cardiac myocytes: TNF alpha inhibition of L-type Ca2+ current and Ca2+ transients. FEBS Lett. 1995;376:24–30
  38. Li XQ, Zhao MG, Mei QB, Zhang YF, Guo W, Wang HF, et al. Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes. Acta. Pharmacol. Sin. 2003;24:1224–1230
  39. Ferrari R. The role of TNF in cardiovascular disease. Pharmacol. Res. 1999;40:97–105
  40. Turner NA, Mughal RS, Warburton P, O'Regan DJ, Ball SG, Porter KE. Mechanism of TNF[alpha]-induced IL-1[alpha], IL-1[beta] and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones. Cardiovasc. Res. 2007;76:81–90
  41. Fantuzzi L, Belardelli F, Gessani S. Monocyte/macrophage-derived CC chemokines and their modulation by HIV-1 and cytokines: a complex network of interactions influencing viral replication and AIDS pathogenesis. J. Leukoc. Biol. 2003;74:719–725
  42. Weisensee D, Bereiter-Hahn J, Schoeppe W, Low-Friedrich I. Effects of cytokines on the contractility of cultured cardiac myocytes. Int. J. Immunopharmacol. 1993;15:581–587
  43. Li YH, Rozanski GJ. Effects of human recombinant interleukin-1 on electrical properties of guinea pig ventricular cells. Cardiovasc. Res. 1993;27:525–530

PII: S0022-2828(09)00102-3

doi: 10.1016/j.yjmcc.2009.02.025

Journal of Molecular and Cellular Cardiology
Volume 47, Issue 2 , Pages 238-246 , August 2009