Journal of Molecular and Cellular Cardiology
Volume 46, Issue 3 , Pages 370-377 , March 2009

Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a

Received 13 November 2008 ,Accepted 13 November 2008.

References 

  1. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, et al. Mesenchymal stem cells modified with Akt Prevent remodeling and restore performance of infarcted hearts. Nat. Med. Sep 2003;9(9):1195–1201
  2. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, et al. Paracrine action acconts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat. Med. Apr 2005;11(4):367–368
  3. Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, et al. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. U. S. A. Jan 2007;104(5):1643–1648
  4. Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signaling from the structures of two Frizzled cysteine-rich domains. Nature. Jul 5 2001;412(6842):86–90
  5. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. Mar 5 2004;303(5663):1483–1487
  6. Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. Aug 11 2006;281(32):22429–22433
  7. Wang S, Krinks M, Lin K, Luyten FP, Moos M. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell. Mar 21 1997;88(6):757–766
  8. Leyns L, Bouwmeester T, Kim SH, Piccolo S, De Robertis EM. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell. Mar 21 1997;88(6):747–756
  9. Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, et al. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. U. S. A. Jun 24 1997;94(13):6770–6775
  10. Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, et al. SARPs: a family of secreted apoptosis-related proteins. Proc. Natl. Acad. Sci. U. S. A. Dec 9 1997;94(25):13636–13641
  11. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J. Biol. Chem. Jun 4 1999;274(23):16180–16187
  12. Daniels DL, Weis WI. Beta-catenin directly displaces Groucho/TLE repressors form Tcf/Lef in Wnt-mediated transcription activation. Nat. Struct. Mol. Biol. Apr 2005;12(4):364–371
  13. Uren A, Reichsman F, Anest V, Taylor WG, Muraiso K, Bottaro DP, et al. Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J. Biol. Chem. Feb 11 2000;275(6):4374–4382
  14. Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA. Novel mechanism of Wnt signaling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. Jul 2001;3(7):683–686
  15. Moon RT, Brown JD, Yang-Snyder JA, Miller JR. Structurally related receptors and antagonists complete for secreted Wnt ligands. Cell. Mar 21 1997;88(6):725–728
  16. Yang F, Zeng Q, Yu G, Li S, Wang CY. Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell. Signal. May 2006;18(5):679–687
  17. Lobov IB, Rao S, Carroll TJ, Vallance JE, Ito M, Ondr JK, et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. Sep 15 2005;437(7057):417–421
  18. Nakagiri S, Murakami A, Takada S, Akiyama T, Yonehara S. Viral FLIP enhances Wnt signaling downstream of stabilized beta-catenin, leading to control of cell growth. Mol. Cell. Biol. Nov 2005;25(21):9249–9258
  19. Nygren MK, Dosen G, Hystad ME, Stubberud H, Funderud S, Rian E. Wnt3A activates canonical Wnt signaling in acute lymphoblastic leukaemia (ALL) cells and inhibits the proliferation of B-ALL cell lines. Br. J. Haematol. Feb 2007;136(3):400–413
  20. Deb A, Davis BH, Guo J, Ni A, Huang J, Zhang Z, et al. SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. Stem Cells. Jan 2008;26(1):35–44
  21. Kim K, Pang KM, Evans M, Hay ED. Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol. Biol. Cell. Oct 2000;11(10):3509–3523
  22. Olmeda D, Castel S, Vilaro S, Cano A. Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol. Biol. Cell. Jul 2003;14(7):2844–2860
  23. Pon YL, Wong AS. Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 up-regulation via the beta-catenin/T-cell factor signaling pathway. Mol. Endocrinol. Dec 2006;20(12):3336–3350
  24. Jullig M, Zhang WV, Ferreira A, Stott NS. MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of beta-catenin. Apoptosis. Apr 2006;11(4):627–641
  25. Liu X, Liu W, Yang L, Xia B, Li J, Zuo J, et al. Increased connexin 43 expression improves the migratory and proliferative ability of H9C2 cells by Wnt3a overexpression. Acta. Biochim. Biophys. Sin. (Shanghai). Jun 2007;39(6):391–398
  26. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature. Jul 6 2000;406(6791):86–90
  27. Satoh J, Kuroda Y. Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors. Neuropathology. Jun 2000;20(2):113–123
  28. Lee JL, Lin CT, Chueh LL, Chang CJ. Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis. J. Biol. Chem. Apr 9 2004;279(15):14602–14609
  29. Lee JL, Chang CJ, Chueh LL, Lin CT. Secreted frizzled related protein 2 (sFRP2) decreases susceptibility to UV-induced apoptosis in primary culture of canine mammary gland tumors by NF-kappaB activation or JNK suppression. Breast Cancer Res. Treat. Nov 2006;100(1):49–58
  30. Barandon L, Couffinhal T, Ezan J, Dufourcq P, Costet P, Alzieu P, et al. Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. Circulation. Nov 4 2003;108(18):2282–2289
  31. Roth W, Wild-Bode C, Platten M, Grimmel C, Melkonyan HS, Dichgans J, et al. Secreted frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene. Aug 31 2000;19(37):4210–4220
  32. Jones SE, Jomary C. Secreted frizzled-related proteins: searching for relationships and patterns. Bioessays. Sep 2002;24(9):811–820
  33. He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. Mar 14 1997;275(5306):1652–1654
  34. Wu CH, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J. Biol. Chem. Nov 1 2002;277(44):41762–41769
  35. Lin K, Wang S, Julius MA, Kitajewski J, Moos M, Luyten FP. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc. Natl. Acad. Sci. U. S. A. Oct 14 1997;94(21):11196–11200
  36. Bafico A, Gazit A, Wu-Morgan SS, Yaniv A, Aaronson SA. Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene. May 28 1998;16(21):2819–2825
  37. Lescher B, Haenig B, Kispert A. sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev. Dyn. Dec 1998;213(4):440–451
  38. Duprez D, Leyns L, Bonnin MA, Lapointe F, Etchevers H, De Robertis EM, et al. Expression of Frzb-1 during chick development. Mech. Dev. Dec 1999;89(1–2):179–183
  39. Baranski M, Berdougo E, Sandler JS, Darnell DK, Burrus LW. The dynamic expression pattern of frzb-1 suggests multiple roles in chick development. Dev. Biol. Jan 1 2000;217(1):25–41
  40. Esteve P, Morcillo J, Bovolenta P. Early and dynamic expression of cSfrp1 during chick embryo development. Mech. Dev. Oct 2000;97(1–2):217–221
  41. Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, et al. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev. Biol. Feb 15 2000;218(2):183–198
  42. Terry K, Magan H, Baranski M, Burrus LW. Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development. Mech. Dev. Oct 2000;97(1–2):177–182
  43. Jin EJ, Erickson CA, Takada S, Burrus LW. Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo. Dev. Biol. May 1 2001;233(1):22–37
  44. Galli LM, Barnes T, Cheng T, Acosta L, Anglade A, Willert K, et al. Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. Dev. Dyn. Mar 2006;235(3):681–690
  45. Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ. Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J. Neurosci. Mar 1 2001;21(5):RC132
  46. Wawrzak D, Métioui M, Willems E, Hendrickx M, de Genst E, Leyns L. Wnt3a binds to several Sfrps in the nanomolar range. Biochem. Biophys. Res. Commun. Jun 15 2007;357(4):1119–1123
  47. Sun X, Zhang R, Lin X, Xu X. Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6. Circ. Res. Apr 11 2008;102(7):831–839

PII: S0022-2828(08)01410-7

doi: 10.1016/j.yjmcc.2008.11.016

Journal of Molecular and Cellular Cardiology
Volume 46, Issue 3 , Pages 370-377 , March 2009

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