Journal of Molecular and Cellular Cardiology
Volume 46, Issue 3 , Pages 378-384 , March 2009

Mesenchymal stem cells improve outcomes of cardiopulmonary resuscitation in myocardial infarcted rats

  • Tong Wang

      Affiliations

    • Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
    • Department of Emergency Medicine, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
  • ,
  • Wanchun Tang

      Affiliations

    • Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
    • Department of Emergency Medicine, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
    • The Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author. Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA. Tel.: +1 760 778 4911; fax: +1 760 778 3468.
  • ,
  • Shijie Sun

      Affiliations

    • Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
    • The Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
  • ,
  • Zhi Wan

      Affiliations

    • Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
  • ,
  • Tingyan Xu

      Affiliations

    • Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
  • ,
  • Zitong Huang

      Affiliations

    • Department of Emergency Medicine, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
  • ,
  • Max Harry Weil

      Affiliations

    • Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA 92270, USA
    • The Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA

Received 8 August 2008 ,Revised 29 October 2008 ,Accepted 13 November 2008.

References 

  1. Bossaert LL. Fibrillation and defibrillation of the heart. Br. J. Anaesth. 1997;79:203–213
  2. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. 2001;344:1750–1757
  3. Jain M, Pfister O, Roger J, Hajjar RJ, Liao R. Mesenchymal stem cells in the infarcted heart. Coron. Artery Dis. 2005;16:93–97
  4. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ. Res. 2004;95:9–20
  5. Grinnemo KH, Mansson A, Dellgren G, Klinberg D, Wardell E, Dryota V, et al. Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium. J. Thorac. Cardiovasc. Surg. 2004;127:1293–1300
  6. Dai W, Hale SL, Martin BJ, Kuang JO, Dow JS, Wold LE, et al. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation. 2005;112:214–223
  7. Price MJ, Chou CC, Frantzen M, Miyamoto T, Kar S, Lee S, et al. Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties. Int. J. Cardiol. 2006;111(2):231–239
  8. Wollert KC, Meyer GP, Lotz J, Ringes-Lichenberg S, Lippolt P, Breidenbach C, et al. Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST randomized controlled clinical trial. Lancet. 2004;364:141–148
  9. Chen SL, Fang WW, Ye F, Liu YN, Qian J, Shan SJ, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol. 2004;94:92–95
  10. Imanishi Y, Saito A, Komoda H, Kitogawa-Sakakida S, Miyagawa S, Kondoh H, et al. Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats. J. Mol. Cell. Cardiol. 2008;44:662–671
  11. Wang T, Tang W, Sun S, Ristagno G, Huang L, Weil MH. Intravenous infusion of bone marrow mesenchymal stem cells improves myocardial function in a rat model of myocardial ischemia. Crit. Care Med. 2007;35(11):2587–2593
  12. Liu XH, Bai CG, Xu ZY, Huang SD, Yuan Y, Gong DJ, et al. Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction. Microvasc. Res. 2008;76(1):23–30
  13. Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infracted myocardium: feasibility, cell migration, and body distribution. Circulation. 2003;108:863–868
  14. Wang CC, Chen CH, Lin WW, Hwang SM, Hsieh PG, Lai PH, et al. Direct intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction. Cardiovasc. Res. 2008;77(3):515–524
  15. Dohmann HF, Perin EC, Takiya CM, Hwang SM, Hsieh PG, Lai PH, et al. Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomicopathologic and immunohistochemical findings. Circulation. 2005;112:521–526
  16. Perin EC, Silva GV, Assad JA, Silva GV, Silva SA, Sensa AL, et al. Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction. J. Mol. Cell. Cardiol. 2008;44(3):486–495
  17. Katritsis DG, Sotiropoulou PA, Karvouni E, Vela D, Buja LM, Sousa AL, et al. Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter. Cardiovasc. Interv. 2005;65(3):321–329
  18. Perin EC. The use of stem cell therapy for cardiovascular disease. Tex. Heart Inst. J. 2005;32:390–392
  19. Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, et al. Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation. 2005;112:1451–1461
  20. Huang L, Weil MH, Sun S, Sun S, Cammarata G, Cao L, et al. Levosimendan improves postresuscitation outcomes in a rat model of CPR. J. Lab. Clin. Med. 2005;146:256–261
  21. Li H, Yu B, Zhang Y, Pan Z, Xu W, Li H. Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes. Biochem. Biophys. Res. Commun. 2006;341:320–325
  22. Sun S, Weil MH, Tang W, Kamohara T, Klouche K. Delta-opioid receptor agonist reduces severity of postresuscitation myocardial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2004;287(2):H969–H974
  23. Miyagawa S, Sawa Y, Taketani S, Kawaguchi N, Nakamura T, Matsuura N, et al. Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Circulation. 2002;105:2556–2561
  24. Weil MH, Sun S. Clinical review: devices and drugs for cardiopulmonary resuscitation — opportunities and restraints. Crit. Care. 2005;9(3):287–290
  25. Ngaage DL, Cale AR, Cowen ME, Griffin S, Guvendik L. Early and late survival after surgical revascularization for ischemic ventricular fibrillation/tachycardia. Ann. Thorac. Surg. 2008;85(4):1278–1281
  26. Kannel WB, Cupples LA, D'Agostino RB. Sudden death risk in overt coronary heart disease: the Framingham Study. Am. Heart J. 1987;113(3):799–804
  27. Nagaya N, Kangawa K, Itoh T, Iwase T, Murakami S, Miyahara Y, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation. 2005;112:1128–1135
  28. Hahn JY, Cho HJ, Kang HJ, Kim TS, Kim MH, Chung JH, et al. Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J. Am. Coll. Cardiol. 2008;51(9):933–943
  29. Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, Xu M, et al. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J. Mol. Cell. Cardiol. 2008;44(2):281–292
  30. Sun L, Cui M, Wang Z, Feng X, Mao J, Chen P, et al. Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction. Biochem. Biophys. Res. Commun. 2007;357(3):779–784
  31. Tang J, Xie Q, Pan G, Wang J, Wang M. Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion. Eur. J. Cardiothorac. Surg. 2006;30:353–361
  32. Schenk S, Mal N, Finan A, Zhang M, Kiedrowski M, Popovic Z, et al. Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells. 2007;25:245–251
  33. Sam J, Angoulvant D, Fazel S, Weisel RD, Li RK. Heart cell implantation after myocardial infarction. Coron. Artery Dis. 2005;16:85–91
  34. Ye NS, Chen J, Luo GA, Zhang RL, Zhao YF, Wang YM. Proteomic profiling of rat bone marrow mesenchymal stem cells induced by 5-azacytidine. Stem Cells Dev. 2006;15:665–676
  35. Hashemi SM, Ghods S, Kolodgie FD, Parcham-Azad K, Keane M, Hamamdzic D, et al. A placebo controlled, dose-ranging, safety study of allogenic mesenchymal stem cells injected by endomyocardial delivery after an acute myocardial infarction. Eur. Heart J. 2008;29(2):251–259
  36. Ladage D, Brixius K, Steingen C, Mehlhorn U, Schwinger RH, Bloch W, et al. Mesenchymal stem cells induce endothelial activation via paracine mechanisms. Endothelium. 2007;14(2):53–63
  37. Wollert KC, Drexler H. Clinical applications of stem cells for the heart. Circ. Res. 2005;96:151–163
  38. Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, et al. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am. J. Physiol. Heart Circ. Physiol. 2006;290:H2196–H2203
  39. Picinich SC, Mishra PJ, Mishra PJ, Glod J, Banerjee D. The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy. Expert. Opin. Biol. Ther. 2007;7(7):965–973
  40. Giordano A, Galderisi U, Marino IR. From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells. J. Cell. Physiol. 2007;211(1):27–35
  41. Perin EC. Stem cell therapy for cardiovascular disease. Tex. Heart Inst. J. 2006;33:204–208
  42. Tang YL, Zhao Q, Qin X, Shen L, Cheng L, Ge J, et al. Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann. Thorac. Surg. 2005;80(1):229–236
  43. Mazhari R, Hare JM. Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche. Nat. Clin. Pract. Cardiovasc. Med. 2007;4(Suppl. 1):S21–S26
  44. Bocchi EA, Bacal F, Guimarães G, Mendroni A, Mocelin A, Filho AE, et al. Granulocyte-colony stimulating factor or granulocyte-colony stimulating factor associated to stem cell intracoronary infusion effects in non ischemic refractory heart failure. Int. J. Cardiol. 2008, Jul 31;[Epub ahead of print]
  45. Tang W, Weil MH, Sun S, Gazmuri RJ, Bisera J, et al. Progressive myocardial dysfunction after cardiac resuscitation. Crit. Care Med. 1993;21(7):1046–1050
  46. Geocadin RG, Koenig MA, Jia X, Stevens RD, Peberdy MA, et al. Management of brain injury after resuscitation from cardiac arrest. Neurol. Clin. 2008;26(2):487–506
  47. Mills WR, Mal N, Kiedrowski MJ, Ungar R, Forudi F, Popovic B, et al. Stem cell therapy enhances electrical viability in myocardial infarction. J. Mol. Cell. Cardiol. 2007;42(2):304–314

PII: S0022-2828(08)01409-0

doi: 10.1016/j.yjmcc.2008.11.014

Journal of Molecular and Cellular Cardiology
Volume 46, Issue 3 , Pages 378-384 , March 2009