Journal of Molecular and Cellular Cardiology
Volume 44, Issue 3 , Pages 510-519 , March 2008

Fibroblast growth factor receptor 1 gene expression is required for cardiomyocyte proliferation and is repressed by Sp3

Received 30 August 2007 ,Revised 18 December 2007 ,Accepted 18 December 2007.

References 

  1. Dell'Era P, Ronca R, Loco L, Nicoli S, Metra M, Presta M. Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development. Circ Res. 2003;93:414–420
  2. Basilico C, Moscatelli D. The FGF family of growth factors and oncogenes. Adv Cancer Res. 1992;59:115–165
  3. Givol D, Yayon A. Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J. 1992;6:3362–3368
  4. Pasquale EB, Singer SJ. Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library. Proc Natl Acad Sci. 1989;86:5449–5453
  5. Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T, et al. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Dev Biol. 2003;258:252–263
  6. Beiman M, Shilo BZ, Volk T. Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev. 1996;10:2993–3002
  7. Sheikh F, Fandrich R, Kardami E, Cattini PA. Overexpression of long or short FGFR-1 results in FGF-2-mediated proliferation in neonatal cardiac myocyte cultures. Cardiovascular Res. 1999;42:696–705
  8. Engelmann GL, Dionne CA, Jaye MC. Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis. Circ Res. 1993;72:7–19
  9. Liu L, Pasumarthi KBS, Padua RA, Mussaeli H, Fandrich RR, Pierce GN, et al. Adult cardiomyocytes express functional high-affinity receptors for basic fibroblast growth factor. Am J Physiol. 1995;268:H1927–H1938
  10. Sugi Y, Sasse J, Barron M, Lough J. Developmental expression of fibroblast growth factor receptor-1 (cek-1; flg) during heart development. Dev Dyn. 1995;202:115–125
  11. Detillieux KA, Sheikh F, Kardami E, Cattini PA. Biological activities of fibroblast growth factor-2 in the adult myocardium. Cardiovascular Res. 2003;57:8–19
  12. Palmen M, Daemen MJAP, De Windt LJ, Willems J, Dassen WRM, Heeneman S, et al. Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. J Am Coll Cardiol. 2004;44:1113–1123
  13. Jiang ZS, Padua RR, Ju H, Doble BW, Jin Y, Hao J, et al. Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C. Am J Physiol Heart Circ Physiol. 2002;282:H1071–H1080
  14. Philipsen S, Suske G. A tale of three fingers: the family of mammalian Sp/XKLF transcription factor. Nuc Acids Res. 1999;27:2991–3000
  15. DiMario JX. Activation and repression of growth factor receptor gene transcription. Intl J Mol Med. 2002;10:65–71
  16. Parakati R, DiMario JX. Repression of fibroblast growth factor receptor 1 gene expression by E2F4 in skeletal muscle cells. Dev Dyn. 2005;232:119–130
  17. Courey AJ, Tjian R. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell. 1988;55:887–898
  18. Seyed M, DiMario JX. Sp1 is required for transcriptional activation of the fibroblast growth factor receptor 1 gene in neonatal cardiomyocytes. Gene. 2007;400:150–157
  19. Patel SG, Funk PE, DiMario JX. Regulation of avian fibroblast growth factor receptor 1 (FGFR-1) gene expression during skeletal muscle differentiation. Gene. 1999;237:265–276
  20. Patel SG, DiMario JX. Two distal Sp1-binding cis-elements regulate fibroblast growth factor receptor 1 (FGFR1) gene expression in myoblasts. Gene. 2001;270:171–180
  21. Parakati R, DiMario JX. Sp1-and Sp3-mediated transcriptional regulation of the fibroblast growth factor receptor 1 gene in chicken skeletal muscle cells. J Biol Chem. 2002;277:9278–9285
  22. Li L, He S, Sun JM, Davie JR. Gene regulation by Sp1 and Sp3. Biochem Cell Biol. 2004;82:460–471
  23. Parakati R, DiMario JX. Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis. J Biol Chem. 2005;280:21284–21294

PII: S0022-2828(08)00003-5

doi: 10.1016/j.yjmcc.2007.12.008

Journal of Molecular and Cellular Cardiology
Volume 44, Issue 3 , Pages 510-519 , March 2008

Article Tools

* Image Usage & Resolution