Journal of Molecular and Cellular Cardiology
Volume 43, Issue 2 , Pages 210-214 , August 2007

Vascular response to intra-arterial injury in the thrombospondin-1 null mouse

  • Faisal Budhani

      Affiliations

    • Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2
    • ,
  • Katherine A. Leonard

      Affiliations

    • Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2
    • ,
  • Andreas Bergdahl

      Affiliations

    • Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2
    • ,
  • Jimin Gao

      Affiliations

    • Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    • Current address: Institute of Biotherapy, Wenzhou Medical College, Wenzhou, Zhejiang, PR China 325035.
    • ,
  • Jack Lawler

      Affiliations

    • Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    • ,
  • Elaine C. Davis

      Affiliations

    • Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2
    • Corresponding Author InformationCorresponding author. Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montreal, Quebec, Canada H3A 2B2. Tel.: +1 514 398 5893; fax: +1 514 398 5047.

Received 4 April 2007 ,Revised 27 April 2007 ,Accepted 14 May 2007.

References 

  1. Lawler J. The functions of thrombospondin-1 and -2. Curr. Opin. Cell Biol. 2000;12:634–640
  2. Iruela-Arispe ML, Liska DJ, Saga EH, Bornstein P. Differential expression of thrombospondin 1, 2 and 3 during murine development. Dev. Dyn. 1993;197:40–56
  3. Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, et al. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J. Clin. Invest. 1998;101:982–992
  4. Majack RA, Goodman LV, Dixit VM. Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J. Cell Biol. 1988;106:415–422
  5. Majack RA, Cook SC, Bornstein P. Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin. Proc. Natl. Acad. Sci. U. S. A. 1986;83:9050–9054
  6. Sata M, Maejima Y, Adachi F, Fukino K, Saiura A, Sugiura S, et al. A mouse model of vascular injury that induces onset of medial cell apoptosis followed by reproducible neointimal hyperplasia. J. Mol. Cell. Cardiol. 2000;32:2097–2104
  7. Roque M, Fallon JT, Badimon JJ, Zhang WX, Taubman MB, Reis ED. Mouse model of femoral artery denudation injury associated with the rapid accumulation of adhesion molecules on the luminal surface and recruitment of neutrophils. Arterioscler. Thromb. Vasc. Biol. 2000;20:335–342
  8. Chen D, Asahara T, Krasinski K, Witzenbichler B, Yang J, Magner M, et al. Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery. Circulation. 1999;100:849–854
  9. Isenberg JS, Calzada MJ, Zhou L, Guo N, Lawler J, Wang XQ, et al. Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. Matrix Biol. 2005;24:110–123
  10. Khorsandi MJ, Fagin JA, Giannella-Neto D, Forrester JS, Cercek B. Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity. J. Clin. Invest. 1992;90:1926–1931
  11. Smith RL, Blick EF, Coalson J, Stein PD. Thrombus production by turbulence. J. Appl. Physiol. 1972;32:261–264
  12. Stein PD, Sabbah HN. Measured turbulence and its effect on thrombus formation. Circ. Res. 1974;35:608–614
  13. Pimanda JE, Ganderton T, Maekawa A, Yap CL, Lawler J, Kershaw G, et al. Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice. J. Biol. Chem. 2004;279:21439–214348
  14. Bonnefoy A, Daenens K, Feys HB, De Vos R, Vandervoort P, Vermylen J, et al. Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial vWF from cleavage by ADAMTS13. Blood. 2006;107:955–964
  15. Saniabadi AR, Umemura K, Matsumoto N, Sakuma S, Nakashima M. Vessel wall injury and arterial thrombosis induced by a photochemical reaction. Thromb. Haemost. 1995;73:868–872

PII: S0022-2828(07)01052-8

doi: 10.1016/j.yjmcc.2007.05.013

Journal of Molecular and Cellular Cardiology
Volume 43, Issue 2 , Pages 210-214 , August 2007

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