Journal of Molecular and Cellular Cardiology
Volume 43, Issue 2 , Pages 148-158 , August 2007

Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model

  • Wim Anné

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Rik Willems

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Patricia Holemans

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Frank Beckers

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Tania Roskams

      Affiliations

    • Department of Pathology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Ilse Lenaerts

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Hugo Ector

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • ,
  • Hein Heidbüchel

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    • Corresponding Author InformationCorresponding author. Department of Cardiology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium, Europe. Tel.: +32 16 34 42 48; fax: +32 16 34 42 40.

Received 10 October 2006 ,Revised 28 April 2007 ,Accepted 14 May 2007.

References 

  1. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation. 1995;92(7):1954–1968
  2. Li D, Fareh S, Leung TK, Nattel S. Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation. 1999;100(1):87–95
  3. Li D, Shinagawa K, Pang L, Leung TK, Cardin S, Wang Z, et al. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation. 2001;104(21):2608–2614
  4. Willems R, Sipido KR, Holemans P, Ector H, Van de Werf F, Heidbuchel H. Different patterns of angiotensin II and atrial natriuretic peptide secretion in a sheep model of atrial fibrillation. J. Cardiovasc. Electrophysiol. 2001;12(12):1387–1392
  5. Goette A, Staack T, Rocken C, Arndt M, Geller JC, Huth C, et al. Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation. J. Am. Coll. Cardiol. 2000;35(6):1669–1677
  6. Nakashima H, Kumagai K, Urata H, Gondo N, Ideishi M, Arakawa K. Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation. Circulation. 2000;101(22):2612–2617
  7. Savelieva I, John Camm A. Atrial fibrillation and heart failure: natural history and pharmacological treatment. Europace. 2004;5(Suppl. 1):S5–S19
  8. Anne W, Willems R, Van der Merwe N, Van de Werf F, Ector H, Heidbuchel H. Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, and diuretics. Heart. 2004;90(9):1025–1030
  9. Ahmed SH, Clark LL, Pennington WR, Webb CS, Bonnema DD, Leonardi AH, et al. Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease. Circulation. 2006;113(17):2089–2096
  10. Willems R, Ector H, Holemans P, Van De Werf F, Heidbuchel H. Effect of different pacing protocols on the induction of atrial fibrillation in a transvenously paced sheep model. Pacing Clin. Electrophysiol. 2001;24(6):925–932
  11. Martinez-Alcaine MA, Ynaraja E, Corbera JA, Montoya JA. Effect of short-term treatment with bumetanide, quinapril and low-sodium diet on dogs with moderate congestive heart failure. Aust. Vet. J. 2001;79(2):102–105
  12. Kim YK, Mankad S, Kim SJ, Takagi G, Tamura T, Gerdes AM, et al. Adding angiotensin II type 1 receptor blockade to angiotensin-converting enzyme inhibition limits myocyte remodeling after myocardial infarction. J. Card. Fail. 2003;9(3):238–245
  13. Graux P, Carlioz R, Rivat P, Bera J, Guyomar Y, Dutoit A. Wavelength and atrial vulnerability: an endocavitary approach in humans. Pacing Clin. Electrophysiol. 1998;21(1 Pt 2):202–208
  14. Lammers WJ, Schalij MJ, Kirchhof CJ, Allessie MA. Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias. Am. J. Physiol. 1990;259(4 Pt. 2):H1254–H1263
  15. Anne W, Willems R, Roskams T, Sergeant P, Herijgers P, Holemans P, et al. Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation. Cardiovasc. Res. 2005;67(4):655–666
  16. Boixel C, Fontaine V, Rucker-Martin C, Milliez P, Louedec L, Michel JB, et al. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. J. Am. Coll. Cardiol. 2003;42(2):336–344
  17. Li D, Melnyk P, Feng J, Wang Z, Petrecca K, Shrier A, et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation. 2000;101(22):2631–2638
  18. Shinagawa K, Li D, Leung TK, Nattel S. Consequences of atrial tachycardia-induced remodeling depend on the preexisting atrial substrate. Circulation. 2002;105(2):251–257
  19. Schoonderwoerd BA, Van Gelder IC, van Veldhuisen DJ, Tieleman RG, Grandjean JG, Bel KJ, et al. Electrical remodeling and atrial dilation during atrial tachycardia are influenced by ventricular rate: role of developing tachycardiomyopathy. J. Cardiovasc. Electrophysiol. 2001;12(12):1404–1410
  20. Mihm MJ, Yu F, Carnes CA, Reiser PJ, McCarthy PM, Van Wagoner DR, et al. Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation. 2001;104(2):174–180
  21. Takenaka H, Kihara Y, Iwanaga Y, Onozawa Y, Toyokuni S, Kita T, et al. oxidative stress, and extracellular matrix degradation during transition to LV failure in rats with hypertension. J. Mol. Cell. Cardiol. 2006;41(6):989–997
  22. Sakata Y, Yamamoto K, Mano T, Nishikawa N, Yoshida J, Hori M, et al. Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of angiotensin-converting enzyme inhibitor. Circulation. 2004;109(17):2143–2149
  23. Kumagai K, Nakashima H, Urata H, Gondo N, Arakawa K, Saku K. Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. J. Am. Coll. Cardiol. 2003;41(12):2197–2204
  24. Shinagawa K, Mitamura H, Ogawa S, Nattel S. Effects of inhibiting Na(+)/H(+)-exchange or angiotensin converting enzyme on atrial tachycardia-induced remodeling. Cardiovasc. Res. 2002;54(2):438–446
  25. Xu J, Cui G, Esmailian F, Plunkett M, Marelli D, Ardehali A, et al. Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation. Circulation. 2004;109(3):363–368
  26. Wyse DG, Gersh BJ. Atrial fibrillation: a perspective: thinking inside and outside the box. Circulation. 2004;109(25):3089–3095
  27. Sanders P, Morton JB, Davidson NC, Spence SJ, Vohra JK, Sparks PB, et al. Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans. Circulation. 2003;108(12):1461–1468
  28. Osaka T, Itoh A, Kodama I. Action potential remodeling in the human right atrium with chronic lone atrial fibrillation. Pacing Clin. Electrophysiol. 2000;23(6):960–965
  29. Richter B, Derntl M, Marx M, Lercher P, Gossinger HD. Therapy with angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and statins: no effect on ablation outcome after ablation of atrial fibrillation. Am. Heart J. 2007;153(1):113–119
  30. Willems R, Morck ML, Exner DV, Rose SM, Gillis AM. Ventricular high-rate episodes in pacemaker diagnostics identify a high-risk subgroup of patients with tachy-brady syndrome. Heart Rhythm. 2004;1(4):414–421

PII: S0022-2828(07)01049-8

doi: 10.1016/j.yjmcc.2007.05.010

Journal of Molecular and Cellular Cardiology
Volume 43, Issue 2 , Pages 148-158 , August 2007

Article Tools

* Image Usage & Resolution