« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 42, Issue 2
, Pages 280-282
, February 2007
eNOS phosphorylation: A pivotal molecular switch in vasodilation and cardioprotection?
References
- . What's in a name? eNOS and anaphylactic shock. J. Clin. Invest. 2006;116(8):2075–2078
- . Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am. J. Physiol.: Renal. Physiol. 2003;285(2):F178–F190
- . Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 1993;90(13):6252–6256
- . Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ. Res. 1996;79(5):984–991
- Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999;399(6736):597–601
- . Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399(6736):601–605
- Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J. Biol. Chem. 1999;274(42):30101–30108
- The Akt kinase signals directly to endothelial nitric oxide synthase. Curr. Biol. 1999;9(15):845–848
- AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 1999;443(3):285–289
- . Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic. Biol. Med. 2006;41(1):144–153
- . Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?. J. Pharmacol. Exp. Ther. 2001;299(3):818–824
- . Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J. Mol. Cell. Cardiol. 2006;[July 12; electronic publication ahead of print]
- The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ. Res. 1997;81(6):1094–1107
- . Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J. Biol. Chem. 2005;280(13):12944–12955
- . The ubiquitous role of nitric oxide in cardioprotection. J. Mol. Cell. Cardiol. 2006;40(1):16–23
- . Preconditioning of rat heart with monophosphoryl lipid A: a role for nitric oxide. J. Pharmacol. Exp. Ther. 1998;285(3):1274–1279
- . Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction. Toxicology. 2000;155(1–3):37–44
- . Postconditioning: a form of “modified reperfusion” protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ. Res. 2004;95(3):230–232
- Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection. Am. J. Physiol.: Heart Circ. Physiol. 2005;288(2):H954–H961
- Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc. Res. 2006;72(1):152–162
- Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia–reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002;105(12):1497–1502
- Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia–reperfusion injury. Cardiovasc. Res. 2005;65(2):345–355
- Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J. Cardiovasc. Pharmacol. 2004;44(3):348–355
- HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size. Circ. Res. 2005;96(11):1185–1192
- . Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway. J. Am. Coll. Cardiol. 2003;41(3):508–515
- . Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS. J. Mol. Cell. Cardiol. 2003;35(2):185–193
- . Synergistic effects of atorvastatin and sildenafil in cardioprotection—Role of NO. Cardiovasc. Drugs Ther. 2006;20(1):5–8
- Enhanced cardioprotection against ischemia–reperfusion injury with combining sildenafil with low-dose atorvastatin. Cardiovasc. Drugs Ther. 2006;20(1):27–36
- . Cardioprotection mediated by rosiglitazone, a peroxisome proliferator-activated receptor gamma ligand, in relation to nitric oxide. Basic Res. Cardiol. 2006;[Aug 14; electronic publication ahead of print]
- . Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis. J. Sex Med. 2005;2(3):347–355
- . The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: the lowering of the preconditioning threshold. An investigation in eNOS knockout mice. Cardiovasc. Res. 2001;52(2):274–280
- . Anaphylactic shock depends on PI3K and eNOS-derived NO. J. Clin. Invest. 2006;116(8):2244–2251
- . Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived NO in vivo. J. Biol. Chem. 2005;280(11):10040–10046
- Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ. Res. 2001;89(8):709–715
- Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat. Med. 2003;9(11):1370–1376
PII: S0022-2828(06)00975-8
doi: 10.1016/j.yjmcc.2006.10.011
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Molecular and Cellular Cardiology
Volume 42, Issue 2
, Pages 280-282
, February 2007
