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The secondary heart field is a new site of Calcineurin/Nfatc1 signaling for semilunar valve development
27 January 2012
Chieh-Yu Lin, Chien-Jung Lin, Chen-Hao Chen, Richard M. Chen, Bin Zhou, Ching-Pin Chang
Abstract: Semilunar valve malformations are common human congenital heart defects. Bicuspid aortic valves occur in 2–3 percent of the population, and pulmonic valve stenosis constitutes 10% of all con...
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microRNAs in cardiovascular development
27 January 2012
Jinghai Chen, Da-Zhi Wang
Abstract: Heart development requires precise temporal-spatial regulation of gene expression, in which the highly conserved modulation networks of transcription factors accurately control the signaling...
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New insights into microRNA-29 regulation: A new key player in cardiovascular disease
20 January 2012
Yajaira Suárez, Carlos Fernández-Hernando
MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs (22 nucleotides) that represent a new elegant layer of post-transcriptional control of gene expression . They are thought...
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Arrhythmogenic coupling between the Na
+–Ca
2
+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes
Yosuke Okamoto, Makoto Takano, Takayoshi Ohba, Kyoichi Ono
Abstract: Atrial fibrillation, the most common sustained arrhythmia, is believed to be triggered by ectopic electrical activity originating in the myocardial sleeves surrounding the pulmonary veins (P...
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Phospholemman is a Negative Feed-Forward Regulator of Ca2+ in β-Adrenergic Signaling, Accelerating β-Adrenergic Inotropy
20 January 2012
Jason H. Yang, Jeffrey J. Saucerman
Abstract: Sympathetic stimulation enhances cardiac contractility by stimulating β-adrenergic signaling and protein kinase A (PKA). Recently, phospholemman (PLM) has emerged as an important PKA substra...
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